P2.01 INITIAL DATA ON THE NATURAL HISTORY OF APWV IN WEST AFRICAN INFANTS

J. Kips; O. Ayoola; S. Greenwald; W. Balogun; P. Clayton; L. Van Bortel; P. Segers; J.K. Cruickshank

doi:10.1016/j.artres.2009.10.017

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Volume 3, Issue 4, December 2009, Pages 177 - 177

P2.01 INITIAL DATA ON THE NATURAL HISTORY OF APWV IN WEST AFRICAN INFANTS

Authors

J. Kips¹, O. Ayoola⁴, S. Greenwald⁵, W. Balogun⁴, P. Clayton³, L. Van Bortel¹, P. Segers², J.K. Cruickshank⁴

¹Heymans Institute of Pharmacology, Gent University, Gent, Belgium

²BioMMeda, Gent University, Gent, Belgium

³Endocrine Science Research Group School of Clinical & Laboratory Sciences University of Manchester, Manchester, United Kingdom

⁴Cardiovascular Research Group School of Clinical & Laboratory Sciences University of Manchester, Manchester, United Kingdom

⁵Pathology Group, Institute of Cell & Molecular Science, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom

Available Online 3 December 2009.

DOI: 10.1016/j.artres.2009.10.017 How to use a DOI?
Abstract: Introduction: Aortic pulse wave velocity (aPWV) may measure vascular structure and function (distensibility) more precisely than blood pressure (BP). Few data exist on arterial distensibility in infancy; none on the effects of malaria in African children.

Methods: Healthy women with singleton pregnancies were recruited at Adeoyo Maternity Hospital, Ibadan, Nigeria. Measures of anthropometry, resting BP and aPWV using a Doppler device were taken on mothers and their babies at birth and three months later.

Results: 147 mother-baby pairs were measured at birth; 74 mothers had slide-positive malaria. 79 mother-baby pairs were measured at 3 months of age, but only 24 at both times. At birth, mean (SD) aPWV of infants whose mothers had malaria was 4.6 (1.6) m/s and SBP/DBP of 75.0/38.5 mmHg compared with those without 5.6 (1.6) m/s and 72.0/35.8 mmHg. Adjusting for birthweight, these differences were not significant.

By 3 months, children with maternal malaria had aPWV & BP of 7.2 (2.8) m/s and 88.2/47.8 mmHg compared to those without at 7.0 (3.0) m/s and 87.6/48.6 mmHg.

Neonatal aPWV was significantly related only to heart rate (R=0.40;p<0.001), but at 3 months to heart rate (R=0.27;p=0.015) and maternal age (R=0.25;p=0.028), independent of maternal and infant BP.

Discussion: aPWV on average increased during the first three months of life, uncorrelated between birth and 3 months. Children with maternal malaria had slightly lower aPWV at birth, catching up by 3 months. Whether higher aPWV develops sooner in babies with malaria than in those without malaria will be examined in follow-up.
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Journal: Artery Research
Volume-Issue: 3 - 4
Pages: 177 - 177
Publication Date: 2009/12/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.10.017 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - J. Kips
AU  - O. Ayoola
AU  - S. Greenwald
AU  - W. Balogun
AU  - P. Clayton
AU  - L. Van Bortel
AU  - P. Segers
AU  - J.K. Cruickshank
PY  - 2009
DA  - 2009/12/03
TI  - P2.01 INITIAL DATA ON THE NATURAL HISTORY OF APWV IN WEST AFRICAN INFANTS
JO  - Artery Research
SP  - 177
EP  - 177
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.017
DO  - 10.1016/j.artres.2009.10.017
ID  - Kips2009
ER  -

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