P7.01 CAROTID ATHEROSCLEROSIS AND ENDOTHELIAL DISFUNCTION IN YOUNG AND MIDDLE-AGED MEN WITH CORONARY ARTERY DISEASE

DOI

10.1016/j.artres.2009.10.094How to use a DOI?

Abstract

Objective: To determine whether the structural status of carotid arteries and abnormal flow-mediated dilatation (FMD) in the brachial artery identify young and middle-aged men with coronary artery disease (CAD).

Methods: A total of 78 men aged 28 to 50 (mean 43±5) years underwent carotid ultrasound and endothelial function measurements. Angiographically documented CAD was present in 49 patients. Those with arterial hypertension, diabetes mellitus or marked hypercholesterolemia (level of LDL cholesterol ≥4,9mmol/l) were excluded from the study.

Results: Patients with CAD more often were smokers, had a history of premature CAD and low level of HDL cholesterol. The mean carotid intima-media thickness (IMT) was 0.88±0.23mm for patients with CAD and 0.76±0.18mm for patients without CAD (p=0.01). The presence of a carotid IMT≥0.9mm was not significantly differing in both groups. Carotid plaques were present in 45 (91.8%) patients with CAD and in 8 (27.6%) patients without CAD (p<0.001). Patients with CAD more often had multiple plaques (86.7% vs 13.8%, p<0.001). Mean brachial artery FMD was less in patients with CAD (4.5±2.8% vs 5.8±2.2%, p=0.03), but the occurrence of abnormal FMD was the same in both groups.

Conclusion: The presence of carotid plaques in young and middle-aged men is associated with the risk of occurrence of CAD and may be considered as a more powerful surrogate marker for coronary atherosclerosis than the presence of impaired brachial artery FMD and increase in carotid IMT.

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TY  - JOUR
AU  - T.V. Balakhonova
AU  - S.G. Kozlov
AU  - H.A. Mahmudova
AU  - A.A. Lyakishev
AU  - A.N. Rogoza
PY  - 2009
DA  - 2009/12/03
TI  - P7.01 CAROTID ATHEROSCLEROSIS AND ENDOTHELIAL DISFUNCTION IN YOUNG AND MIDDLE-AGED MEN WITH CORONARY ARTERY DISEASE
JO  - Artery Research
SP  - 183
EP  - 183
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.094
DO  - 10.1016/j.artres.2009.10.094
ID  - Balakhonova2009
ER  -