P7.01 CAROTID ATHEROSCLEROSIS AND ENDOTHELIAL DISFUNCTION IN YOUNG AND MIDDLE-AGED MEN WITH CORONARY ARTERY DISEASE

DOI

10.1016/j.artres.2009.10.094How to use a DOI?

Abstract

Objective: To determine whether the structural status of carotid arteries and abnormal flow-mediated dilatation (FMD) in the brachial artery identify young and middle-aged men with coronary artery disease (CAD).

Methods: A total of 78 men aged 28 to 50 (mean 43±5) years underwent carotid ultrasound and endothelial function measurements. Angiographically documented CAD was present in 49 patients. Those with arterial hypertension, diabetes mellitus or marked hypercholesterolemia (level of LDL cholesterol ≥4,9mmol/l) were excluded from the study.

Results: Patients with CAD more often were smokers, had a history of premature CAD and low level of HDL cholesterol. The mean carotid intima-media thickness (IMT) was 0.88±0.23mm for patients with CAD and 0.76±0.18mm for patients without CAD (p=0.01). The presence of a carotid IMT≥0.9mm was not significantly differing in both groups. Carotid plaques were present in 45 (91.8%) patients with CAD and in 8 (27.6%) patients without CAD (p<0.001). Patients with CAD more often had multiple plaques (86.7% vs 13.8%, p<0.001). Mean brachial artery FMD was less in patients with CAD (4.5±2.8% vs 5.8±2.2%, p=0.03), but the occurrence of abnormal FMD was the same in both groups.

Conclusion: The presence of carotid plaques in young and middle-aged men is associated with the risk of occurrence of CAD and may be considered as a more powerful surrogate marker for coronary atherosclerosis than the presence of impaired brachial artery FMD and increase in carotid IMT.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - T.V. Balakhonova
AU  - S.G. Kozlov
AU  - H.A. Mahmudova
AU  - A.A. Lyakishev
AU  - A.N. Rogoza
PY  - 2009
DA  - 2009/12/03
TI  - P7.01 CAROTID ATHEROSCLEROSIS AND ENDOTHELIAL DISFUNCTION IN YOUNG AND MIDDLE-AGED MEN WITH CORONARY ARTERY DISEASE
JO  - Artery Research
SP  - 183
EP  - 183
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.094
DO  - 10.1016/j.artres.2009.10.094
ID  - Balakhonova2009
ER  -