P8.13 CORONARY IMPLANTATION OF SIROLIMUS-ELUTING STENT IMPAIRS THE PERIPHERAL VASCULAR COMPLIANCE IN PATIENT WITH CORONARY ARTERY DISEASE
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- 10.1016/j.artres.2009.10.119How to use a DOI?
- Abstract
Introduction: To the best of our knowledge, any studies evaluated potential influence on peripheral arterial stiffness, measured by pulse wave velocity (PWV), of percoutaneous coronary intervention (PCI) and stenting.
Methods: 150 patients were enrolled and underwent coronary angiography. In 68 patients was performed coronary stenting (PCI group). PWV was invasively obtained before and after coronary stenting.
Results: Coronary stenting produced a significant augment of PWV (from 4.59 to 5.82m/s, P=0.000). In contrast, the sub-population which performed angiography without PCI (noPCI group), didn’t show any significant change in PWV. The analysis of PCI group demonstrated that only implantation of Sirolimus eluting stent (SES) caused a significant increase of PWV (from 4.62 to 6.15m/s, P=0.029). In a stepwise multiple regression model stent length, glycaemia and body mass index were significantly associated with increase of PWV, accounting for a total of 51.7% of the variation (P=0.009). In particular, stent length accounted for 39.6% of the variance in PWV augmentation; glycaemia and body mass index explained an additional 12.1% of its variability. In the same analysis performed in PCI group, stent length accounted for 65.3% of the variance (P=0.024) and other than glycaemia and body mass index, also implantation of SES explained an additional 18.5%.
Conclusion: We have shown, for the first time, a significant association between SES implantation and an central stiffness worsening.
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TY - JOUR AU - M. Vatrano AU - R. Ceravolo AU - C. Nesta AU - A. Ferraro AU - E. Campopiano AU - F. Borrello AU - V. Pascale AU - G. Ciconte AU - V.A. Ciconte PY - 2009 DA - 2009/12/03 TI - P8.13 CORONARY IMPLANTATION OF SIROLIMUS-ELUTING STENT IMPAIRS THE PERIPHERAL VASCULAR COMPLIANCE IN PATIENT WITH CORONARY ARTERY DISEASE JO - Artery Research SP - 189 EP - 190 VL - 3 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2009.10.119 DO - 10.1016/j.artres.2009.10.119 ID - Vatrano2009 ER -