P2.20 PERIPHERAL ARTERY DISEASE DETECTED BY ANKLE-BRACHIAL INDEX IS ASSOCIATED TO CARDIAC AND CAROTID ABNORMALITIES IN PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES

José Pompeu Filho; Ricardo Silva; Rachel Andrade; Leiria Andrade Neto; João Falcão; Sandra Falcão; Luiz Bortolotto*

doi:10.1016/j.artres.2015.10.225

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Volume 12, Issue C, December 2015, Pages 10 - 10

P2.20 PERIPHERAL ARTERY DISEASE DETECTED BY ANKLE-BRACHIAL INDEX IS ASSOCIATED TO CARDIAC AND CAROTID ABNORMALITIES IN PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES

Authors

José Pompeu Filho¹, Ricardo Silva², Rachel Andrade⁴, Leiria Andrade Neto⁴, João Falcão¹, Sandra Falcão¹, Luiz Bortolotto*³

¹Messejana Hospital, Fortaleza, Ceará, Brazil

²Federal University of Ceara, Fortaleza, Ceará, Brazil

³Heart institute (InCor), São Paulo University, São Paulo, São Paulo, Brazil

⁴Eye Hospital Leiria Andrade, Fortaleza, Ceará, Brazil

Available Online 23 November 2015.

DOI: 10.1016/j.artres.2015.10.225 How to use a DOI?
Abstract: Few studies evaluated cardiac or carotid abnormalities in patients with arterial hypertension and diabetes according to the presence of peripheral artery disease detected by abnormal ankle brachial index (ABI). For this purpose, we studied 99 diabetic hypertensive patients with abnormal (n=50, ABI≤0.9 or ABI>1.4) and normal (n=49, ABI>0.9 or ≤1.4) ABI values. All patients underwent successively to echocardiography and carotid ultrasound. From echocardiographic study, we analyzed the occurrence of a composite endpoint that included significant cardiac morphological and functional changes. The mean age was 65.4±7 years and 61.6% were women. It was observed a higher prevalence of left atrial enlargement (46%vs.26,5%, p<0.05), left ventricular hypertrophy (LVH) (56%vs.26.5%, p<0.01), left ventricular systolic dysfunction (12% vs.2%, p<0.05) and left ventricular regional kinetics abnormalities (16vs. 0%, p <0.01) in patients with abnormal ABI. The left ventricle mass (178.6±58vs.149.8±46 g/m², p<0.01) was greater in abnormal ABI group. The echocardiographic composite endpoint was more prevalent in abnormal ABI group (84.0%vs.59.2%, p <0.01). Binary logistic regression analysis showed abnormal ABI as an independent predictor for the occurrence of echocardiographic composite endpoint (OR=3.43; 95%CI=1.07–11.0;p<0.05) and the presence of LVH (OR=4.35, 95%CI=0.42–13.52, p=0.01). Carotid ultrasound revealed a higher frequency of plaque occurrence in common carotid arteries in patients with abnormal ABI (69,6%vs.30,4%, p< 0.05). Also, it was noted a higher number of patients from abnormal ABI group with carotid stenosis>50% (26,5%vs.6.3%; p<0.01). In conclusion, in patients with arterial hypertension and diabetes, the presence of peripheral artery disease detected by abnormal ABI was associated to important structural and functional cardiac and carotid modifications.
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Journal: Artery Research
Volume-Issue: 12 - C
Pages: 10 - 10
Publication Date: 2015/11/23
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.10.225 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - José Pompeu Filho
AU  - Ricardo Silva
AU  - Rachel Andrade
AU  - Leiria Andrade Neto
AU  - João Falcão
AU  - Sandra Falcão
AU  - Luiz Bortolotto*
PY  - 2015
DA  - 2015/11/23
TI  - P2.20 PERIPHERAL ARTERY DISEASE DETECTED BY ANKLE-BRACHIAL INDEX IS ASSOCIATED TO CARDIAC AND CAROTID ABNORMALITIES IN PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES
JO  - Artery Research
SP  - 10
EP  - 10
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.225
DO  - 10.1016/j.artres.2015.10.225
ID  - Filho2015
ER  -

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