P2.20 PERIPHERAL ARTERY DISEASE DETECTED BY ANKLE-BRACHIAL INDEX IS ASSOCIATED TO CARDIAC AND CAROTID ABNORMALITIES IN PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES
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- 10.1016/j.artres.2015.10.225How to use a DOI?
- Abstract
Few studies evaluated cardiac or carotid abnormalities in patients with arterial hypertension and diabetes according to the presence of peripheral artery disease detected by abnormal ankle brachial index (ABI). For this purpose, we studied 99 diabetic hypertensive patients with abnormal (n=50, ABI≤0.9 or ABI>1.4) and normal (n=49, ABI>0.9 or ≤1.4) ABI values. All patients underwent successively to echocardiography and carotid ultrasound. From echocardiographic study, we analyzed the occurrence of a composite endpoint that included significant cardiac morphological and functional changes. The mean age was 65.4±7 years and 61.6% were women. It was observed a higher prevalence of left atrial enlargement (46%vs.26,5%, p<0.05), left ventricular hypertrophy (LVH) (56%vs.26.5%, p<0.01), left ventricular systolic dysfunction (12% vs.2%, p<0.05) and left ventricular regional kinetics abnormalities (16vs. 0%, p <0.01) in patients with abnormal ABI. The left ventricle mass (178.6±58vs.149.8±46 g/m2, p<0.01) was greater in abnormal ABI group. The echocardiographic composite endpoint was more prevalent in abnormal ABI group (84.0%vs.59.2%, p <0.01). Binary logistic regression analysis showed abnormal ABI as an independent predictor for the occurrence of echocardiographic composite endpoint (OR=3.43; 95%CI=1.07–11.0;p<0.05) and the presence of LVH (OR=4.35, 95%CI=0.42–13.52, p=0.01). Carotid ultrasound revealed a higher frequency of plaque occurrence in common carotid arteries in patients with abnormal ABI (69,6%vs.30,4%, p< 0.05). Also, it was noted a higher number of patients from abnormal ABI group with carotid stenosis>50% (26,5%vs.6.3%; p<0.01). In conclusion, in patients with arterial hypertension and diabetes, the presence of peripheral artery disease detected by abnormal ABI was associated to important structural and functional cardiac and carotid modifications.
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TY - JOUR AU - José Pompeu Filho AU - Ricardo Silva AU - Rachel Andrade AU - Leiria Andrade Neto AU - João Falcão AU - Sandra Falcão AU - Luiz Bortolotto* PY - 2015 DA - 2015/11/23 TI - P2.20 PERIPHERAL ARTERY DISEASE DETECTED BY ANKLE-BRACHIAL INDEX IS ASSOCIATED TO CARDIAC AND CAROTID ABNORMALITIES IN PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES JO - Artery Research SP - 10 EP - 10 VL - 12 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2015.10.225 DO - 10.1016/j.artres.2015.10.225 ID - Filho2015 ER -