Interrelationships between macro and microvascular structure and function
- DOI
- 10.1016/j.artres.2010.10.001How to use a DOI?
- Keywords
- Antihypertensive therapy; Macrocirculation; Microcirculation
- Abstract
Macrovasculature and microvasculature are interrelated, and may influence each other. Microvascular structure is not only the site of vascular resistance but probably also the origin of most of the wave reflections generating increased central systolic blood pressure. Some index of large artery stiffness seems to be related with the media to lumen ratio of subcutaneous small resistance arteries of hypertensive patients. In addition, both microvascular structural alterations and changes in the mechanical properties of large arteries represent potent predictors of prognosis. In addition, drugs that may improve microvascular structure may also correct alterations in the mechanical properties of large arteries In fact, while β-blocking agents and diuretics have a negligible effect on microvascular structure, renin-angiotensin system antagonists and calcium entry blockers have favorable actions, improving also large artery mechanics and possibly reducing central wave reflections.
- Copyright
- © 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
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TY - JOUR AU - Damiano Rizzoni AU - Maria Lorenza Muiesan AU - Enzo Porteri AU - Carolina De Ciuceis AU - Gianluca E.M. Boari AU - Massimo Salvetti AU - Anna Paini AU - Enrico Agabiti Rosei PY - 2010 DA - 2010/10/29 TI - Interrelationships between macro and microvascular structure and function JO - Artery Research SP - 114 EP - 117 VL - 4 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2010.10.001 DO - 10.1016/j.artres.2010.10.001 ID - Rizzoni2010 ER -