5.1 ASSESSMENT OF THE ARTERIAL WALL BEHAVIOR ALONG THE COMMON CAROTID ARTERY AT THE LEVEL OF A PLAQUE ACCORDING TO ARTERIAL STIFFNESS GRADIENT

H. Beaussier; I. Masson; O. Naggara; D. Calvet; R. Joannides; E. Guegan-Massardier; E. Gérardin; E. Bozec; P. Boutouyrie; S. Laurent

doi:10.1016/j.artres.2009.10.159

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Volume 3, Issue 4, December 2009, Pages 155 - 155

5.1 ASSESSMENT OF THE ARTERIAL WALL BEHAVIOR ALONG THE COMMON CAROTID ARTERY AT THE LEVEL OF A PLAQUE ACCORDING TO ARTERIAL STIFFNESS GRADIENT

Authors

H. Beaussier¹, I. Masson², O. Naggara³, D. Calvet³, R. Joannides⁴, E. Guegan-Massardier⁴, E. Gérardin⁴, E. Bozec¹, P. Boutouyrie¹, S. Laurent¹

¹Department of Pharmacology and INSERM URMS 872, Hôpital Européen Georges Pompidou, Paris, France

²Institut d’Alembert, UMR CNRS 7190, Université Pierre et Marie Curie and UMR CNRS 7054, Paris, France

³Departments of Neurology and Neuroradiology, EA 4055 Centre Hospitalier Sainte-Anne, Paris, France

⁴Departments of Pharmacology and Neurology and INSERM URM 644, CHU Rouen, Paris, France

Available Online 3 December 2009.

DOI: 10.1016/j.artres.2009.10.159 How to use a DOI?
Abstract: Background: We previously described longitudinal strain gradient named bending strain (BS), along the common carotid artery (CCA) with two distinct patterns (Paini, Stroke 2007, Beaussier, Hypertension 2008): Pattern A (larger radial strain at the plaque level than at adjacent CCA) and its opposite, Pattern B.

Aim: To assess the role of change in CCA thickness (IMT) and medial diameter (D) during the cardiac cycle at the level of plaques according to functional patterns of BS.

Method: 45 CCA were analysed at the level of the plaque in 26 patients. Mechanical parameters were measured at 128 sites on a 4 cm long CCA segment by an echotracking system (ArtLab®). Plaque composition was determined by magnetic resonance imaging (MRI). For each plaque, systolo(s)-diastolic(d) variation of IMT and D were calculated. We obtained ΔIMT ((IMTs - IMTd)/IMTd), ΔDiameter ((Ds - Dd)/Dd) and ratio R (ΔIMT/ΔD).

Results: R did not significantly differ according to remodeling pattern neither to plaque composition. Plaques exhibiting Pattern B (n=25) were characterized by an R 73 % higher than plaques exhibiting Pattern A (n=20) (5.9 ± 3.0 versus 3.4 ± 1.6, p<0.005). In other words, IMT strain is disproportionately larger than diameter strain among Pattern B than among pattern A.

Conclusion: The arterial stiffness gradient at the level of the plaque may influence the arterial wall behavior: an inward BS may be associated with exaggerated compressibility and local stresses within the wall in comparison to an outward BS with reduced local stresses.
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Journal: Artery Research
Volume-Issue: 3 - 4
Pages: 155 - 155
Publication Date: 2009/12/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.10.159 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - H. Beaussier
AU  - I. Masson
AU  - O. Naggara
AU  - D. Calvet
AU  - R. Joannides
AU  - E. Guegan-Massardier
AU  - E. Gérardin
AU  - E. Bozec
AU  - P. Boutouyrie
AU  - S. Laurent
PY  - 2009
DA  - 2009/12/03
TI  - 5.1 ASSESSMENT OF THE ARTERIAL WALL BEHAVIOR ALONG THE COMMON CAROTID ARTERY AT THE LEVEL OF A PLAQUE ACCORDING TO ARTERIAL STIFFNESS GRADIENT
JO  - Artery Research
SP  - 155
EP  - 155
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.159
DO  - 10.1016/j.artres.2009.10.159
ID  - Beaussier2009
ER  -

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