Artery Research

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Volume 3, Issue 4, December 2009, Pages 154 - 154

3.6 OSTEOPROTEGERIN IS ASSOCIATED INDEPENDENTLY WITH AORTIC STIFFNESS IN PATIENTS WITH ATHEROSCLEROSIS AND IN HEALTHY SUBJECTS

Authors
M. Zagura1, M. Sergejev2, J. Lieberg3, P. Kampus4, A. Peetsalu5, J. Eha6, M. Zilmer7, J. Kals8
1Department of Biochemistry, University of Tartu, Tartu, Estonia
2Department of Cardiology, University of Tartu, Tartu, Estonia
3Department of Surgery, University of Tartu, Tartu, Estonia
4Department of Cardiology, University of Tartu, Tartu, Estonia
5Department of Surgery, University of Tartu, Tartu, Estonia
6Department of Cardiology, University of Tartu, Tartu, Estonia
7Department of Biochemistry, University of Tartu, Tartu, Estonia
8Department of Biochemistry, University of Tartu, Tartu, Estonia
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.157How to use a DOI?
Abstract

Background: Arterial stiffening is an independent predictor for cardiovascular mortality. Preliminary studies have shown that arterial calcification may have impact on increased vascular stiffness. However, little is known about the role of calcification inhibitor osteoprotegerin (OPG) as an independent predictor of arterial stiffness in patients with peripheral arterial disease (PAD) and in healthy subjects.

Aim: To evaluate the association between OPG level and arterial stiffness parameters in patients with PAD and in healthy subjects.

Materials and methods: We studied 59 males with PAD (age 63±7 years) and 44 healthy subjects (age 54±7 years). Serum OPG level was measured using ELISA kit. Arterial stiffness parameters, such as aortic pulse wave velocity aPWV and augmentation index, were determined by applanation tonometry using the Sphygmocor device.

Results: OPG level (5.40±1.77 vs 4.19±1.14 (pmol/L); p<0.001) and aPWV (9.86±2.31 vs 7.69±1.66 (m/s); p<0.001) were different for the patients and for the controls. There was linear relationship between OPG level and aPWV in patients with PAD (R=0.51, p=0.0001) as well as in healthy individuals (R=0.47; p=0.002). In multiple regression models, OPG level was independently associated with aPWV along with age and mean arterial pressure in the patient group (R2=0.34; p=0.034) as well as in the controls (R2=0.49; p=0.037)

Conclusion: The independent association between OPG level and aPWV in patients with PAD and in controls suggests that calcification inhibitor OPG may be important in the process of aortic stiffening in atherosclerosis and in healthy subjects.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
3 - 4
Pages
154 - 154
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.157How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - M. Zagura
AU  - M. Sergejev
AU  - J. Lieberg
AU  - P. Kampus
AU  - A. Peetsalu
AU  - J. Eha
AU  - M. Zilmer
AU  - J. Kals
PY  - 2009
DA  - 2009/12/03
TI  - 3.6 OSTEOPROTEGERIN IS ASSOCIATED INDEPENDENTLY WITH AORTIC STIFFNESS IN PATIENTS WITH ATHEROSCLEROSIS AND IN HEALTHY SUBJECTS
JO  - Artery Research
SP  - 154
EP  - 154
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.157
DO  - 10.1016/j.artres.2009.10.157
ID  - Zagura2009
ER  -