Artery Research

Volume 3, Issue 4, December 2009, Pages 180 - 180

P3.02 GLUCOSE METABOLISM IMPAIRMENT IN METABOLIC SYNDROME IS LINKED WITH INCREASED PULSE WAVE VELOCITY

Authors
A.L. Lieber1, C. Vesin1, M.E. Safar1, B.I. Levy2, J. Blacher1
1Hotel Dieu, Paris, France
2Hopital Lariboisiere, Paris, France
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.031How to use a DOI?
Abstract

Introduction: Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors. The specificity of each component of metabolic syndrome improves its management.

Objective: Do patients with MetS have arterial modifications? Which MetS components are they most closely linked to?

Materials and methods: Our population recorded 348 patients (185 men and 163 women). These patients entered the day hospital in order to have a cardiovascular check-up. We measured brachial and central blood pressure, augmentation index, and pulse wave velocity (PWV).

Results: 150 patients did have a metabolic syndrome (MetS+) and 198 did not (MetS-). PWV is higher in MetS+ patients, but it does not sustain after adjustment with confounding factors. Within this population, 93 have diabetes mellitus and multiple parameter correlation of PWV with each of MetS components in this population show a significant association with glucose metabolism impairment only.

MetS+ no diabetes diabetes p

(n=150) (n=57) (n=93)
PWV (m/s) 13.74±3.66 12.71±3.49 14.35±3.65 0.0027
PWV (m/s) (*) 12.94±3.06 14.11±2.99 0.0259
PWV (m/s) (*) & MetS_HDL 12.96±3.15 14.15±3.02 0.0261
PWV (m/s) (*) & MetS_WC 13.07±3.50 14.22±3.55 0.0283
PWV (m/s) (*) & MetS_TG 12.96±3.07 14.08±3.11 0.0371
PWV (m/s) (*) & MetS_HTA 13.79±11.34 15.00±15.06 0.0227
PWV (m/s) (*) & MetS_Glyc 12.93±3.07 13.88±4.98 0.1484

Conclusion:

MetS+ patients have a higher PWV than MetS- patients but this difference disappears after adjustment to classic factors.

Diabetic patients have a significantly higher PWV even after adjustment.

When performing multiple parameter relationship with different components of MetS, we find that only glucose metabolism impairment is independently and positively correlated to PWV.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
180 - 180
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.031How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - A.L. Lieber
AU  - C. Vesin
AU  - M.E. Safar
AU  - B.I. Levy
AU  - J. Blacher
PY  - 2009
DA  - 2009/12/03
TI  - P3.02 GLUCOSE METABOLISM IMPAIRMENT IN METABOLIC SYNDROME IS LINKED WITH INCREASED PULSE WAVE VELOCITY
JO  - Artery Research
SP  - 180
EP  - 180
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.031
DO  - 10.1016/j.artres.2009.10.031
ID  - Lieber2009
ER  -