P3.02 GLUCOSE METABOLISM IMPAIRMENT IN METABOLIC SYNDROME IS LINKED WITH INCREASED PULSE WAVE VELOCITY

DOI

10.1016/j.artres.2009.10.031How to use a DOI?

Abstract

Introduction: Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors. The specificity of each component of metabolic syndrome improves its management.

Objective: Do patients with MetS have arterial modifications? Which MetS components are they most closely linked to?

Materials and methods: Our population recorded 348 patients (185 men and 163 women). These patients entered the day hospital in order to have a cardiovascular check-up. We measured brachial and central blood pressure, augmentation index, and pulse wave velocity (PWV).

Results: 150 patients did have a metabolic syndrome (MetS+) and 198 did not (MetS-). PWV is higher in MetS+ patients, but it does not sustain after adjustment with confounding factors. Within this population, 93 have diabetes mellitus and multiple parameter correlation of PWV with each of MetS components in this population show a significant association with glucose metabolism impairment only.

	MetS+	no diabetes	diabetes	p
	(n=150)	(n=57)	(n=93)
PWV (m/s)	13.74±3.66	12.71±3.49	14.35±3.65	0.0027
PWV (m/s) (*)		12.94±3.06	14.11±2.99	0.0259
PWV (m/s) (*) & MetS_HDL		12.96±3.15	14.15±3.02	0.0261
PWV (m/s) (*) & MetS_WC		13.07±3.50	14.22±3.55	0.0283
PWV (m/s) (*) & MetS_TG		12.96±3.07	14.08±3.11	0.0371
PWV (m/s) (*) & MetS_HTA		13.79±11.34	15.00±15.06	0.0227
PWV (m/s) (*) & MetS_Glyc		12.93±3.07	13.88±4.98	0.1484

Conclusion:

MetS+ patients have a higher PWV than MetS- patients but this difference disappears after adjustment to classic factors.

Diabetic patients have a significantly higher PWV even after adjustment.

When performing multiple parameter relationship with different components of MetS, we find that only glucose metabolism impairment is independently and positively correlated to PWV.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - A.L. Lieber
AU  - C. Vesin
AU  - M.E. Safar
AU  - B.I. Levy
AU  - J. Blacher
PY  - 2009
DA  - 2009/12/03
TI  - P3.02 GLUCOSE METABOLISM IMPAIRMENT IN METABOLIC SYNDROME IS LINKED WITH INCREASED PULSE WAVE VELOCITY
JO  - Artery Research
SP  - 180
EP  - 180
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.031
DO  - 10.1016/j.artres.2009.10.031
ID  - Lieber2009
ER  -