Natural Dyes as Photosensitizers of Propionibacterium acnes

DOI

10.2991/978-94-6463-322-1_20How to use a DOI?

Keywords

Photosensitizers; PDT; Natural dyes; Propionibacterium acnes; Acne vulgaris

ABSTRACT

The patient’s quality of life may be negatively impacted by the high prevalence of acne vulgaris among adolescents. Acne vulgaris is a skin condition in which hair follicles become clogged with dead skin cells, bacteria, and natural facial oils. It has been demonstrated that acne antibiotics raise antibacterial resistance. According to this study, natural dyes could treat Propionibacterium acnes-caused acne vulgaris. β-carotene, riboflavin, and curcumin mediated the activity of PDT against Propionibacterium acnes in vitro. Various types of light (red light λ640 nm, blue light λ423 nm, and green light λ532 nm), irradiation times of 10, 30, and 60 min and dye concentrations of 0.005, 0.010, and 0.015% were tested. An ELISA reader 595 nm measured the cell viability. Propionibacterium acnes was not inhibited by dyes alone. PDT activity was observed after being treated with the appropriate light and natural dye combination. Blue light inhibited Propionibacterium acnes growth more effectively than green light (41.9 vs. 14.0%). Red light, on the other hand, has no effect. With 10–30 min PDT treatment of β-carotene, riboflavin, and curcumin, bacterial survival was reduced by 41.9, 28.60, and 12.51%. Due to their cost and antibacterial effect, a concentration of 0.10% dyes was suggested for further use. Antibacterial PDT containing curcumin, riboflavin, or β-carotene may be an alternative treatment for acne vulgaris.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Asmiyenti Djaliasrin Djalil
AU  - Aqshal Pramudya Susanto
AU  - Rizal Nandha Arisugita
AU  - Binar Asrining Dhiani
AU  - Muhammad Faris Maulidan
AU  - Irfan Zamzani
PY  - 2023
DA  - 2023/12/30
TI  - Natural Dyes as Photosensitizers of Propionibacterium acnes
BT  - Proceedings of the Conference on Natural Resources And Life Sciences 2022 (NRLS-BIO 2022)
PB  - Atlantis Press
SP  - 145
EP  - 151
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-322-1_20
DO  - 10.2991/978-94-6463-322-1_20
ID  - Djalil2023
ER  -