Clarification of the irritating and toxic effects of bentonite-like clays

DOI

10.2991/isils-19.2019.82How to use a DOI?

Keywords

enterosorbent, montmorillonite, ulcerative pathology, inflammatory process

Abstract

This article studies the action and biocompatibility of the developed montmorillonite-containing preparation “Sorbent” on experimental animals with its long-term use. The local irritating effect of the “Sorbent” preparation was evaluated by its effect on the gastric mucosa of animals with experimental ulcerative pathology. The size of the most common particles in the suspension is 5-8 microns. The experiments were carried out on white rats of the Wistar line and non-linear Hartley guinea pigs. To identify the irritating effect, the drug was administered to animals in therapeutic doses of 200 mg/kg and three times the conditionally therapeutic dose - 600 mg/kg of body weight. Destructive changes in the stomachs of experimental animals were studied macroscopically. The ulcerogenic effect was evaluated by calculating the Pauls index.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Alexander Vezentsev
AU  - Vladimir Bukhanov
AU  - Alexander Lopanov
AU  - Nikolay Zuev
AU  - Ulyana Krut
AU  - Galina Shaidorova
PY  - 2019/11
DA  - 2019/11
TI  - Clarification of the irritating and toxic effects of bentonite-like clays
BT  - Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)
PB  - Atlantis Press
SP  - 65
EP  - 70
SN  - 2468-5747
UR  - https://doi.org/10.2991/isils-19.2019.82
DO  - 10.2991/isils-19.2019.82
ID  - Vezentsev2019/11
ER  -