Bioscreening of the spacerized complex BIS (2-Pyridyl)-3-(1,2,4-Triazolyl) propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid

DOI

10.2991/isils-19.2019.19How to use a DOI?

Keywords

spacerized complex bis (2-Pyridyl) -3- (1,2,4-Triazolyl) Propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid, bioscreening, rats

Abstract

scientific work is devoted to the study of the biological activity spacerized complex bis(2-Pyridyl) -3- (1,2,4-Triazolyl) Propane And 11-Hydroxy-1,1-Ethylidenediphosphonic Acid in the dose range from 5 to 200 mg / kg. The results of the study of acute toxicity showed that spacering of the HDA+BTP complex reduces its toxicity by 1.4 times in comparison with characteristics of its precursor components. It was found that the test compound exhibits a dose-dependent hypotensive and vasorelaxating effect, sedative, anxiogenic and analgesic effects.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Elena Chuyan
AU  - Marina Ravaeva
AU  - Igor Cheretaev
AU  - Olga Kornilenko
AU  - Anastasia Furkovskaya
AU  - Elena Birukova
PY  - 2019/11
DA  - 2019/11
TI  - Bioscreening of the spacerized complex BIS (2-Pyridyl)-3-(1,2,4-Triazolyl) propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid
BT  - Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)
PB  - Atlantis Press
SP  - 184
EP  - 188
SN  - 2468-5747
UR  - https://doi.org/10.2991/isils-19.2019.19
DO  - 10.2991/isils-19.2019.19
ID  - Chuyan2019/11
ER  -