The Effect of the Bicyclononan Derivative on the Conditioned Reflex of Passive Avoidance in Rats with Cerebral Ischemia

DOI

10.2991/isils-19.2019.14How to use a DOI?

Keywords

bicyclononan, nootropics, memory, cerebral ischemia, antiamnestic effect, rats

Abstract

The aim of this study was to develop the effect of substance Z–109 - a bicyclononan derivative, presumably belonging to the class of ampakines on the memory of rats undergoing cerebral ischemia. The evaluation of mnestic functions was carried out on the model of the conditioned passive avoidance reflex. Ischemic brain damage was reproduced by 200 in rats of both sexes - occlusion of the middle cerebral artery, photoinduced thrombosis in the prefrontal cortex, complete ligation of both carotid arteries. The test substance was found to have a positive effect at doses of 2.5 mg / kg, 13 mg/kg and 25 mg / kg in the treatment of various types of ischemic brain damage, the substance had a maximum effect at a dose of 2.5 mg / kg. The investigated substance is possible for prospective study as a neuroprotective anti-stroke agent

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Galina Brkich
AU  - Natalia Pyatigorskaya
AU  - Andrey Nedorubov
AU  - Olga Filippova
AU  - Oleg Zyryanov
PY  - 2019/11
DA  - 2019/11
TI  - The Effect of the Bicyclononan Derivative on the Conditioned Reflex of Passive Avoidance in Rats with Cerebral Ischemia
BT  - Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)
PB  - Atlantis Press
SP  - 164
EP  - 168
SN  - 2468-5747
UR  - https://doi.org/10.2991/isils-19.2019.14
DO  - 10.2991/isils-19.2019.14
ID  - Brkich2019/11
ER  -