Analysis of Challenges and Progress AIDS Vaccine Research

DOI

10.2991/978-2-38476-297-2_135How to use a DOI?

Keywords

AIDS; Vaccine research; Challenge; Progress

Abstract

Since the first report of AIDS (acquired immunodeficiency syndrome) caused by human immunodeficiency virus (HIV) in 1981, this disease has become a serious social and public health problem worldwide. Scientists have always been committed to developing an efficient AIDS vaccine. This article discusses the research of AIDS vaccine and the difficulties encountered in its development. First of all, there is no ideal animal experimental model for AIDS vaccine research. Given that HIV is a virus specific to humans, there is currently no animal model that can fully simulate the process of human HIV infection, which poses challenges for vaccine development and testing. Furthermore, the envelope protein of HIV-1 does not inherently possess the ability to induce broad-spectrum neutralizing antibodies. The envelope protein of HIV is considered one of the key targets of vaccine research, but most existing antibodies induced by HIV-1 envelope protein can only neutralize some virus strains, so they cannot provide comprehensive protection. However, the latest scientific research suggests that the stable epitopes of HIV-1 envelope proteins contribute to the maturation and evolution of widely neutralizing antibodies. This new discovery has opened up a new direction and clue for the research and development of HIV vaccine. Targeted activation or enhancement of immune response to these conservative epitopes will help to generate antibodies with extensive neutralizing activity, thus creating the possibility of developing an effective AIDS vaccine.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Yuhan Guo
AU  - Tete Yin
AU  - Xiaoyan Geng
AU  - Ziliang Liu
AU  - Yutian Wang
AU  - Xinnuan Gao
AU  - Tianhui Gao
AU  - Linghan Zheng
PY  - 2024
DA  - 2024/10/31
TI  - Analysis of Challenges and Progress AIDS Vaccine Research
BT  - Proceedings of the 2024 8th International Seminar on Education, Management and Social Sciences (ISEMSS 2024)
PB  - Atlantis Press
SP  - 1128
EP  - 1143
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-297-2_135
DO  - 10.2991/978-2-38476-297-2_135
ID  - Guo2024
ER  -