The Study of the Transgeneration Genotoxic Effect of Drugs Based on the Analysis of Synaptonemal Complexes in Mouse Spermatocytes

DOI

10.2991/isees-18.2018.27How to use a DOI?

Keywords

synaptonemal complex, meiosis, transgeneration effect, drugs, genotoxicity

Abstract

The research employs immmunocytochemical methods to study the synaptonemal complexes (SC), and it targets the primary spermatocytes of mice from the offspring of males who received antimicrobials The males in the offspring of fathers received bacteriophage, nitrofural and cifran. When comparing the total number of damaged cells, they did not show a significant difference with the control animals. However, when comparing the spectrum of affects, they presented a significantly increased number of cells having ring SC-bivalents in the offspring of males treated with cifran. This may indicate an increase in chromosome fragility, leading to the deletion of telomere regions of chromosomes, which in turn causes the formation of ring bivalents.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Maret M. Atsayeva
AU  - Zura I. Bisultanova
AU  - Petimat M. Dzhambetova
AU  - Nadezhda Yu. Oyun
AU  - Oksana L. Kolomiets
PY  - 2018/12
DA  - 2018/12
TI  - The Study of the Transgeneration Genotoxic Effect of Drugs Based on the Analysis of Synaptonemal Complexes in Mouse Spermatocytes
BT  - Proceedings of the International Symposium “Engineering and Earth Sciences: Applied and Fundamental Research” (ISEES 2018)
PB  - Atlantis Press
SP  - 137
EP  - 141
SN  - 2352-5401
UR  - https://doi.org/10.2991/isees-18.2018.27
DO  - 10.2991/isees-18.2018.27
ID  - Atsayeva2018/12
ER  -