Effects of CYP2D6*4 Polymorphism in the Developmet of Ploygenetic Diseases in Chechen Poplulation

DOI

10.2991/isees-18.2018.26How to use a DOI?

Keywords

CYP2D6 polymorphism, diabetes mellitus, urogenital system, acute cerebrovascular disease, breast cancer, Chechen population

Abstract

The polymorphic variant of the CYP2D6 A18496G gene was studied as one of the most clinically significant in the MFD etiology in the Chechen population. Statistically significant effect of the GA genotype in relation to malignant breast tumors in women (OR = 1.93 at 95% CI = 1.20-3.09, p = 0.005) and the increase of the renal diseases risk and development of diabetes were revealed. Heterozygous genotype of patients with acute cerebrovascular disease ensures the protective effect.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Z.I. Bisultanova
AU  - L.G. Molochaeva
AU  - P.M. Dzhambetova
AU  - Maret M. Atsayeva
AU  - Elbek A. Machigov
AU  - Aishet M. Plieva
PY  - 2018/12
DA  - 2018/12
TI  - Effects of CYP2D6*4 Polymorphism in the Developmet of Ploygenetic Diseases in Chechen Poplulation
BT  - Proceedings of the International Symposium “Engineering and Earth Sciences: Applied and Fundamental Research” (ISEES 2018)
PB  - Atlantis Press
SP  - 133
EP  - 136
SN  - 2352-5401
UR  - https://doi.org/10.2991/isees-18.2018.26
DO  - 10.2991/isees-18.2018.26
ID  - Bisultanova2018/12
ER  -