Mechanical and Morphological Properties of 3D Printed Scaffold for Tissue Engineering Application

DOI

10.2991/978-94-6463-589-8_53How to use a DOI?

Keywords

scaffold design; bone tissue engineering; 3D print; DentaMODEL

Abstract

Currently available designs for tissue engineering scaffold often focus on a structure that mimics the extracellular matrix while ignoring the mechanical properties needed for load bearing. This study aims to overcome the problems of existing scaffold designs by introducing new biologically and mechanically relevant scaffold designs for bone tissue. To reach these goals, new scaffold designs embedded with square, circular and hexagonal pores at three different pore sizes of 0.25, 0.30 and 0.35 were prepared using computer aided design (CAD) software. Their mechanical properties were modeled, and the physical and mechanical properties of the 3D-printed scaffolds were evaluated. Two materials, including PLA and acrylic resin were used to 3D print the scaffolds to ensure accurate control over the scaffold’s structure and porosity. The mechanical properties of the scaffolds with three different pore sizes of 0.25, 0.30 and 0.35 mm were analysed using finite element analysis (FEA) and experimental testing. The results showed that the cubic design with circular pores displays the highest stress and strain values. The simulations indicate stress levels of 189.76 MPa and strain values of 9.4983%. Experimentally, it indicates stress values of 71.589 MPa and strain values of 58.92%. These values exceed those of the cubic designs with hexagonal and square pores. The results show that the proposed scaffold designs meet both biological and mechanical requirements, therefore contributing to the development of enhanced bone tissue engineering.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Muhammad Azmin Wafi Mohammed Noor
AU  - Abdul Manaf Abdullah
AU  - Abdul Halim Abdullah
AU  - Solehuddin Shuib
AU  - Zulkifli Abdul Ghaffar
PY  - 2024
DA  - 2024/12/01
TI  - Mechanical and Morphological Properties of 3D Printed Scaffold for Tissue Engineering Application
BT  - Proceedings of the International Conference on Innovation & Entrepreneurship in Computing, Engineering & Science Education (InvENT 2024)
PB  - Atlantis Press
SP  - 565
EP  - 577
SN  - 2352-538X
UR  - https://doi.org/10.2991/978-94-6463-589-8_53
DO  - 10.2991/978-94-6463-589-8_53
ID  - Noor2024
ER  -