Vitamin D3 and Selenium Supplementation and Renal Hyper-filtration State in Metabolic Syndrome Patients

DOI

10.2991/ahsr.k.211012.023How to use a DOI?

Keywords

Glycosylation gap, metabolic syndrome, renal-filtration, Selenium, mitochondrial function and vitamin D3

Abstract

Objective: This work aimed to study the effect of supplanting vitamin D3 and selenium on the renal-filtration status and glycosylation- gap in metabolic syndrome patients. Subjects and methods: This pre-post study conducted on 93 patients referred from different general /or private internal medicine clinics with metabolic syndrome to the Soran private laboratory–Erbil. Patients present with at least three of five criteria of metabolic syndrome according to NCEP ATP III. Vitamin D estimation using the enzyme-linked fluorescent assay (ELFA) technique. Mitochondrial function analysis involved measurement of serum lactate and serum pyruvate by fluorescence-based methods. L-Carnitine was assayed using colourimetric /fluoro- metric. e-GFR calculated by equation. Results: The results shows that metabolic syndrome patient supplementing with vitamin D3 and selenium significantly elevated serum Vitamin D3 that associated with reduction in both systolic and diastolic blood pressure (p<0.001). HbA1c, serum fructosamine, Glycosylation gap also significant reduction (p<0.001). Serum triglycerides significantly decrease (p<0.001) with a significant increase in HDL-C (p<0.001). Renal function profile shows that serum creatinine significantly elevated after the treatment in contrast e-GFR, urinary albumin and Albumin/ creatinine ratio reduced after the treatment (p< 0.001). Mitochondrial function profile shows that after supplements treatment, mitochondrial function parameters return to normal values in comparison to before treatment (p<0.001). Conclusion: supplementing vitamin D3 and Selenium to metabolic syndrome patient significantly reduce hyper-filtration status by activating mitochondrial function in these patients, so it can used as a protective measure in the treatment of metabolic syndrome patients.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Muhammad A. Ahmed
PY  - 2021
DA  - 2021/10/12
TI  - Vitamin D3 and Selenium Supplementation and Renal Hyper-filtration State in Metabolic Syndrome Patients
BT  - Proceedings of the 1st International Ninevah Conference on Medical Sciences (INCMS 2021)
PB  - Atlantis Press
SP  - 134
EP  - 139
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211012.023
DO  - 10.2991/ahsr.k.211012.023
ID  - Ahmed2021
ER  -