Facile way of surface modification on hydrogel for drug delivery

DOI

10.2991/imst-16.2016.5How to use a DOI?

Keywords

surface modification; hydrogel; drug delivery; ß-cyclodextrin (ß-CD).

Abstract

Although hydrogel has some outstanding performance, traditional hydrogel still has some drawbacks in the application of drug delivery field. Herein, we introduced a simple and effective way to improve the performance of tradition hydrogel for drug delivery. ß-cyclodextrin (ß-CD) functionized hydrogel was acquired through a two-step facile way, that is, alkaline hydrolysis and epichlorohydrin crosslinking. Though the reaction ratio of alkaline hydrolysis and the grafting ratio of ß-CD varied slightly according different detection methods, successful modification as well as proper properties including contact angle, equilibrium water content and surface morphology was still approved through the results of this work. The equilibrium amount of loading orfloxacin in hydrogels increased significantly with the increase of drug concentration and the equilibrium amount of loading orfloxacin in ß-CD modified hydrogel was superior to that in traditional hydrogel with significant difference. The loading drug concentration as well as ß-CD had effects on drug release behaviors.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xin Wang
AU  - Pin Chen
AU  - Xiaohong Hu
PY  - 2016/11
DA  - 2016/11
TI  - Facile way of surface modification on hydrogel for drug delivery
BT  - Proceedings of the 2016 International Conference on Innovative Material Science and Technology (IMST 2016)
PB  - Atlantis Press
SP  - 35
EP  - 41
SN  - 1951-6851
UR  - https://doi.org/10.2991/imst-16.2016.5
DO  - 10.2991/imst-16.2016.5
ID  - Wang2016/11
ER  -