Tombelu Extract (Bactronophorus Sp) Inhibits Plasmodium Falciparum Metabolism In Vitro

DOI

10.2991/978-94-6463-392-4_18How to use a DOI?

Keywords

Tombelu; Bactronophorus sp; P. falciparum; anti-malaria

Abstract

Malaria is still a serious public health problem in the world, including Indonesia, because it is found with a fairly high prevalence. Malaria is a pathological condition caused by Plasmodium which is transmitted through the bite of the Anopheles mosquito. Subjects who live in endemic areas or have had malaria can become carriers of the parasite. Tombelu (Bactronophorus sp) is believed by coastal communities to be able to increase stamina and overcome various diseases including malaria. The research objective was to determine the effectiveness of Tombelu extract (Bactronophorus sp) in inhibiting the metabolism of Plasmodium falciparum. Method: This study used a quasi-experimental in Vitro design. Plasmodium falciparum was obtained from the blood of identified symptomatic malaria patients in endemic and non-endemic areas. The treatment group was divided into a normal control group (no treatment), a negative control group: administration of distilled water, treatment F1: administration of 10% tombelu water extract, and treatment F2: administration of 100% tombelu water extract. Plasmodium readings were carried out at 100 LPB (large field of view). The research was carried out in 2018 in East Kolaka and Kendari City. The data collected was the form of Plasmodium falciparum which was identified on a microscope using the thick blood drop method. Data is processed and analyzed descriptively. Results: 9 Plasmodium forms merozites, tripozoites and gametozites. Plasmodium was identified at the 12th (gametocytes), 40th (2 trophozoites), 60th (3 gametocytes), 72nd (trophozoites), and 90th (2 gametocytes) large visual fields. In negative control: Plasmodium identified 4 plasmodium tropozite and gametozite forms. Added tubeTombelu (Bactronophorus sp) at 10% and 100% dilution did not identify Plasmodium falciparum. Conclusion: Giving Tombelu aqueous extract (Bactronophorus sp) at 10% and 100% dilution can inhibit the metabolism of Plasmodium falciparum. Suggestion. It is important to carry out further research to develop the benefits of Tombelu (Bactronophorus sp) as a functional food.

Copyright

© 2024 The Author(s)

Open Access

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TY  - CONF
AU  - Wiralis Wiralis
AU  - Teguh Fathurrahman
AU  - Hariani Hariani
AU  - Suwarni Suwarni
PY  - 2024
DA  - 2024/04/22
TI  - Tombelu Extract (Bactronophorus Sp) Inhibits Plasmodium Falciparum Metabolism In Vitro
BT  - Proceedings of the 1st International Conference Medical and Health Science Halu Oleo (IMHO 2023)
PB  - Atlantis Press
SP  - 153
EP  - 163
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-392-4_18
DO  - 10.2991/978-94-6463-392-4_18
ID  - Wiralis2024
ER  -