Arthritis Assay on Combination of Red Ginger (Zingiber Officinale) and Secang Wood (Caesalpinia Sappan) Extract Towards Rat Oedema Induced by Complete Freund’s Adjuvant

DOI

10.2991/aer.k.211215.099How to use a DOI?

Keywords

Rheumatoid arthritis; Red ginger; Secang wood; Edema volume

Abstract

Rheumatoid arthritis is a systemic chronic autoimmune disease associated with multiple inflammatory mediators leading to joint destruction, synovial and cartilage inflammation. Treatment often used for rheumatoid arthritis is DMARD which causes dangerous effects, such as gastrointestinal bleeding, nausea, dyspepsia, and impaired kidney function. The side effects of this treatment have caused many rheumatoid arthritis sufferers to turn into herbal medicines that have milder side effects. The purpose of this study was to determine the anti-arthritis effect of red ginger and secang wood combination ethanol extract based on decrease of oedema volume and the percentage of oedema inhibition. The method used was adjuvant-induced arthritis by subplantar induction of Complete Freund’s Adjuvant. Animal model used was 35 Wistar rats divided into 7 groups. The results showed that the suspension of red ginger and secang wood combination in 0.5% CMC at the F2 (red ginger extract 14 mg/200 g BW + secang wood extract 102 mg/200 g BW) had the best anti-arthritis effect with the percentage of inhibition of reducing oedema by 76.09% and having a significant anti-arthritis effect (p<0.05) compared to the negative control in terms of decreasing the volume of oedema.

Copyright

© 2021 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Rizka Amalia
AU  - Tukiran
AU  - Suyatno Suyatno
AU  - Fauzia Sabila
PY  - 2021
DA  - 2021/12/16
TI  - Arthritis Assay on Combination of Red Ginger (Zingiber Officinale) and Secang Wood (Caesalpinia Sappan) Extract Towards Rat Oedema Induced by Complete Freund’s Adjuvant
BT  - Proceedings of the International Joint Conference on Science and Engineering 2021 (IJCSE 2021)
PB  - Atlantis Press
SP  - 584
EP  - 589
SN  - 2352-5401
UR  - https://doi.org/10.2991/aer.k.211215.099
DO  - 10.2991/aer.k.211215.099
ID  - Amalia2021
ER  -