Proceedings of the 4th International Conference on Life Sciences and Biotechnology (ICOLIB 2021)

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Genetic and Epigenetic Aspects of Amelogenesis Imperfecta and Dentinogenesis Imperfecta

Authors
Nurulia Januarti1, Francisca Veyta Ayu2, Ria Puspitawati3, Elza Ibrahim Auerkari3, *
1Pediatric Dentistry Residency Program, Faculty of Dentistry, University of Indonesia, Salemba Raya Street, No. 4, Jakarta, 10430, Indonesia
2Master Program of Basic Dental Science-Forensic Odontology, Faculty of Dentistry, University of Indonesia, Kampus UI Salemba, Jakarta, 10430, Indonesia
3Department of Oral Biology-Division Forensic Odontology, Faculty of Dentistry, University of Indonesia, Salemba Raya Street, No. 4, Jakarta, 10430, Indonesia
*Corresponding author. Email: elza.ibrahim@ui.ac.id
Corresponding Author
Elza Ibrahim Auerkari
Available Online 22 December 2022.
DOI
10.2991/978-94-6463-062-6_43How to use a DOI?
Keywords
Amelogenesis imperfecta; Dentinogenesis imperfecta; Genetic; Epigenetic
Abstract

Amelogenesis imperfecta (AI) and dentinogenesis imperfecta (DGI) are hereditary dental disorders. AI is a developmental condition resulting in enamel defects of all or almost all teeth. The prevalence ranges from 1:700 to 1:14,000 for AI and from 1:6000 to 1:8000 for DGI. DGI is a collective of autosomal dominant conditions of anomalous dentine structures affecting either the primary or both the deciduous and permanent dentitions. AI is caused by disturbed developmental processes, such as mutations of the AMELX gene that encodes secretion of extracellular matrix proteins from ameloblasts during enamel formation. AI can also arise due to mutations in several other genes that encode proteins with a role in amelogenesis. DGI results from mutations in the gene encoding dentine sialophosphoprotein (DSPP), COL1A1 and COL1A2. In addition, both AI and DGI can be promoted by interference of the regulatory functions of key genes through influence by environmental factors such as trauma, chemicals or systemic diseases, and epigenetic factors such as DNA methylation. This paper aims to review the genetic and epigenetic etiological factors of AI and DGI.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 4th International Conference on Life Sciences and Biotechnology (ICOLIB 2021)
Series
Advances in Biological Sciences Research
Publication Date
22 December 2022
ISBN
978-94-6463-062-6
ISSN
2468-5747
DOI
10.2991/978-94-6463-062-6_43How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Nurulia Januarti
AU  - Francisca Veyta Ayu
AU  - Ria Puspitawati
AU  - Elza Ibrahim Auerkari
PY  - 2022
DA  - 2022/12/22
TI  - Genetic and Epigenetic Aspects of Amelogenesis Imperfecta and Dentinogenesis Imperfecta
BT  - Proceedings of the 4th International Conference on Life Sciences and Biotechnology (ICOLIB 2021)
PB  - Atlantis Press
SP  - 435
EP  - 443
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-062-6_43
DO  - 10.2991/978-94-6463-062-6_43
ID  - Januarti2022
ER  -