Patch Formulation of Celery Leaves Extract (Apium Graveolens L.) As Mosquito Repellent

DOI

10.2991/assehr.k.210415.019How to use a DOI?

Keywords

patch, repellent, PVA, PVP

Abstract

the transdermal patch preparation which contains repellent active substances. The combination of PVA and PVP polymers can produce strong, non- breakable, elastic, and transparent preparations. This study aims to determine the concentration of the right combination of PVA and PVP to produce a safe and stable preparation. The repellent patch is made using the active substance of the methanol extract of celery leaves (Apium graveolens.L) which is useful as a natural repellent. This study used an experimental method with the active substance of leaf methanol extract Celery (Apium graveolens.L) obtained from the maceration process is then vacuum distilled. The extract used was 15% for each formula with variations in the combination of PVA and PVP for the control formula and formula I 1: 1, formula II 1: 1,5, and formula III 1: 2. After being formulated, the preparation will be evaluated for 28 days of storage which includes pH test, weight uniformity, thickness, percentage of moisture, folding resistance, and organoleptic. The evaluation results showed that all the repellent patch formulas met the requirements for 28 days of storage. All formulas have a pH that tends to increase with a pH range of 4.52-6.95, has an increase in weight with a range of 0.1443-0.1553, has a thickness that tends to increase with a range of 0.21-0.30, has an increase in the percentage of moisture with a range of 5.79% -7.94%, did not experience damage or breakage after folding> 300 times and did not experience a change in color and odor. Leaf methanol extract celery (Apium graveolens.L) can be formulated into a stable and fulfilling repellent patch preparation with the most optimal formula is formula II with a combination of polymer concentration is 1: 1.5.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ratnaningsih Dewi Astuti
AU  - Siti Khotimah
PY  - 2021
DA  - 2021/04/19
TI  - Patch Formulation of Celery Leaves Extract (Apium Graveolens L.) As Mosquito Repellent
BT  - Proceedings of the First International Conference on Health, Social Sciences and Technology (ICoHSST 2020)
PB  - Atlantis Press
SP  - 83
EP  - 87
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.210415.019
DO  - 10.2991/assehr.k.210415.019
ID  - Astuti2021
ER  -