The Potential of Brucella Suis Local Isolate As Vaccine Candidate For Controlling Brucellosis On Pigs In Indonesia

DOI

10.2991/icoh-17.2018.65How to use a DOI?

Keywords

Brucella suis, vaccine candidate, local isolates

Abstract

Brucellosis in Pigs not only cause great economic losses due to a decrease in productivity of livestock but also are zoonotic. Prevention efforts mainly addressed to vaccination and sanitary measures and governance. S19 and RB51 vaccine does not provide protection against infection and abortion in pigs infected with Brucella suis. To solve the above problems, it needs to be pursued manufacture of local strains in order to improve the performance of the vaccine. as a model bacterial vaccine, which is expected to produce a better immune response. The aim of research to develop a vaccine Brucella suis isolates locally as a vaccine candidate against Brucellosis in pigs and then to prevent the spread of brucellosis. The method used laboratory exploration methods followed by experimental studies using experimental animals mice. The procedure of research: determining the dose of infection, determining the doses of the vaccine, and challenge test. This study used a factorial design. F test analysis used to test the titer of antibodies through CFT methods.The results showed that local isolates attenuated Brucella suis at a concentration of 108 were able to show a good antibody titer is 128. This research concluded that local isolates of Brucellasuis has the ability to protect mice from infection with bacteria Brucellasuis, and the ability of high immunogenicity.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Emy Koestanti Sabdoningrum
AU  - Sri Chusniati
AU  - Lilik Maslachah
AU  - Widya Paramita Lokapirnasari
PY  - 2017/07
DA  - 2017/07
TI  - The Potential of Brucella Suis Local Isolate As Vaccine Candidate For Controlling Brucellosis On Pigs In Indonesia
BT  - Proceedings of the 1st International Conference in One Health (ICOH 2017)
PB  - Atlantis Press
SP  - 322
EP  - 325
SN  - 2468-5739
UR  - https://doi.org/10.2991/icoh-17.2018.65
DO  - 10.2991/icoh-17.2018.65
ID  - Sabdoningrum2017/07
ER  -