Optimization of Ethanol Concentration and Time for Flavonoid Extraction of Melinjo Peel

DOI

10.2991/aer.k.211221.017How to use a DOI?

Keywords

Anti-hyperuricemia; Extraction; Flavonoids; Melinjo Peel

Abstract

The peel of melinjo (Gnetum gnemon) has potential as an anti-hyperuricemia. The content of flavonoids in the melinjo peel can inhibit the xanthine oxidase enzyme as a catalyst for the formation of uric acid compounds. The purpose of this study was to obtain the optimum extraction time and ethanol concentration for the extraction of flavonoids from the green melinjo peel using the maceration technique with heating and stirring. This research used response surface methodology (RSM) and central composite design (CCD). Factor 1 was the extraction time (X1) with a lower limit of 60 minutes and an upper limit of 120 minutes, and factor 2 was the ethanol concentration (X2) with a lower limit of 30% and an upper limit of 70%. The responses were tested for a total of flavonoid, yield, and water content. The results showed that the optimum conditions were 5.11 minutes and 70% for the ethanol concentration. Verifying the optimum conditions, obtained melinjo peel extract had a total flavonoid 5.255 mg QE/g, moisture content of 5.766%, and a yield of 33.657%. The deviations from the program prediction results were 3.47%, 4.63%, and 0.55%, respectively.

Copyright

© 2021 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Sucipto
AU  - Ismi Fadilla Ainur Husna
AU  - Sri Kumalaningsih
PY  - 2021
DA  - 2021/12/23
TI  - Optimization of Ethanol Concentration and Time for Flavonoid Extraction of Melinjo Peel
BT  - Proceedings of the International Conference on Innovation and Technology (ICIT 2021)
PB  - Atlantis Press
SP  - 127
EP  - 133
SN  - 2352-5401
UR  - https://doi.org/10.2991/aer.k.211221.017
DO  - 10.2991/aer.k.211221.017
ID  - 2021
ER  -