A Novel Ca-Alginate Nanogel Mediated by Glycyrrhizic Acid

DOI

10.2991/icimm-15.2015.130How to use a DOI?

Keywords

Sodium Alginate; Glycyrrhizic Acid; Nanogels

Abstract

A novel glycyrrhizic acid (GA) mediated Calcium-alginate nanogel was successfully prepared by using GA, calcium chloride (CaCl2) and sodium alginate (SA) through reverse W/O microemulsion combined with controlled internal gelation method. Nanogels were characterized by Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (XRD), differential scanning calorimetry (DSC). The mean particle size of GA-Ca-alginate nanogels was 42.54 nm, and the polydispersity index (PdI) was 0.154. Furthermore, GA-Ca-alginate nanogels possessed charged negatively surface with a zeta potential of -44.7 mV. The biocompatibility of GA-Ca-alginate nanogels indicated that no toxicity was found in HepG2 cells. The novel nanogels prepared here have obvious advantages of smaller particle size and may be potential for drug delivery applications.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xiaoning Zhu
AU  - Li-Na Gao
AU  - Yuanlu Cui
PY  - 2015/07
DA  - 2015/07
TI  - A Novel Ca-Alginate Nanogel Mediated by Glycyrrhizic Acid
BT  - Proceedings of the 5th International Conference on Information Engineering for Mechanics and Materials
PB  - Atlantis Press
SP  - 690
EP  - 694
SN  - 2352-5401
UR  - https://doi.org/10.2991/icimm-15.2015.130
DO  - 10.2991/icimm-15.2015.130
ID  - Zhu2015/07
ER  -