Preparation of a Thermosensitive Guanidine-Chitosan/Poloxamer in situ Gel for Intranasal Delivery System

DOI

10.2991/icimm-15.2015.129How to use a DOI?

Keywords

Themosensitive hydrogel; Orthogonal Design; Guanidine-Chitosan; Poloxamer

Abstract

A novel themosensitive in situ gel was prepared by using Poloxamer407 and poloxamer188 combined with membrane penetration enhancer Guanidine-Chitosan. Orthogonal experiment optimization was used to study of formulations conditions that suit to intranasal drug delivery. The optimal intranasal gel formulation has been further checked for viscosity behavior against temperature. The result showed that the optimal formulation was 18% P407 (w/w), 3% P188 (w/w), 2% GCS (w/w), which have prospective gelation temperature 29.5 °C. Evaluation of Guanidine-chitosan influence in gelation temperature showed slight decrease the point of hydrogel system.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yingzong Ren
AU  - Xue-Jie Qi
AU  - Yuanlu Cui
PY  - 2015/07
DA  - 2015/07
TI  - Preparation of a Thermosensitive Guanidine-Chitosan/Poloxamer in situ Gel for Intranasal Delivery System
BT  - Proceedings of the 5th International Conference on Information Engineering for Mechanics and Materials
PB  - Atlantis Press
SP  - 686
EP  - 689
SN  - 2352-5401
UR  - https://doi.org/10.2991/icimm-15.2015.129
DO  - 10.2991/icimm-15.2015.129
ID  - Ren2015/07
ER  -