The Analysis Of Rbmy1 STS RBMI Microdeletion Gene On Azoospermic Factor (Azf) Region Of The Y Chromosome In Infertile Men In Palembang

DOI

10.2991/icihc-18.2019.32How to use a DOI?

Keywords

Infertile men, infertility, microdeletions, Azoospermic Factor, AZF region, Y chromosome.

Abstract

Approximately 50-80 million couples have infertility problems, and every year appeared about 2 million new infertile couples. As many as 40% of them are caused by male factors. Male infertility generally occursdue to abnormal spermatozoa. One of the causes is related to the deletion of gene onAzoospermic Factor (AZF) regionof the Y chromosome. One of the candidate genes in that region is RBMY1. This study is a descriptive study that aims to determine the molecular frequency RBMY1 gene microdeletion in AZF region of the Y chromosome uses STS RBM1 in infertile men in Palembang. The number of samples was 39 people. The analysis was done by using Polymerase Chain Reaction (PCR) and electrophoresis on 2% agarose gel. From this research, it was found that the frequency of microdeletions on the AZF region of the Y chromosome uses STS RBM1 of infertile men in Palembang was 7.7%. Further studies onmicrodeletion region of Azoospermic factor (AZF) of the Y chromosome in interfile menin Palembang, with other genes or by using criteria on only male factor, for example oligozoospermia, oligozoospermia extreme or cryptozoospermia were used as samples.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Tedy Febriyanto
PY  - 2019/04
DA  - 2019/04
TI  - The Analysis Of Rbmy1 STS RBMI Microdeletion Gene On Azoospermic Factor (Azf) Region Of The Y Chromosome  In Infertile Men In Palembang
BT  - Proceedings of the 1st International Conference on Inter-professional Health Collaboration (ICIHC 2018)
PB  - Atlantis Press
SP  - 129
EP  - 132
SN  - 2468-5739
UR  - https://doi.org/10.2991/icihc-18.2019.32
DO  - 10.2991/icihc-18.2019.32
ID  - Febriyanto2019/04
ER  -