Morphofunctional Changes of the Kidneys in Non-Tumour Cholestasis

DOI

10.2991/ahsr.k.201001.038How to use a DOI?

Keywords

duration of cholestasis, homeostatic disorders, structural changes of the liver and kidneys, preoperative preparation, the functional ability of the kidneys

Abstract

The morphofunctional changes of kidneys at cholestasis of various duration in 170 patients suffered from obstructive jaundice of non-neoplastic aetiology were analyzed. Taking part in the processes of the metabolism of biologically active substances, including hormones, the liver has a regulatory effect on many kidney functions, including filtration and resorption. It was revealed that the depth of homeostatic disorders is directly dependent on the duration of cholestasis and the level of bilirubinemia in biliary obstruction, leading to significant functional and structural lesions of the kidneys. Thus, in the case of cholestasis lasting up to 10 days, there was a moderate decrease in diuresis without renal dysfunction, with 2 weeks of jaundice, both a decrease in diuresis and a moderate decrease in glomerular filtration were detected, and a fluctuation within the subnormal values of tubular reabsorption, with cholestasis 3-6 weeks, along with a pronounced decrease in diuresis, the functional ability of the kidneys were reduced. It was proved that the conducted complex conservative therapy led to stabilization of the function of the kidneys and facilitate better tolerance to the operations caused by the improving of the liver function.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - M.D. Kashaeva
AU  - K.V. Gavrilova
AU  - D.S. Dyukov
AU  - A.V. Proshin
AU  - L.G. Proshina
AU  - V.A. Golushko
PY  - 2020
DA  - 2020/10/03
TI  - Morphofunctional Changes of the Kidneys in Non-Tumour Cholestasis
BT  - Proceedings of the International Conference “Health and wellbeing in modern society” (ICHW 2020)
PB  - Atlantis Press
SP  - 188
EP  - 192
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.201001.038
DO  - 10.2991/ahsr.k.201001.038
ID  - Kashaeva2020
ER  -