Immune System of Primary School-Age Children With Functional Respiratory Disorders in the Conditions of Anthropogenic Influence

DOI

10.2991/ahsr.k.201001.014How to use a DOI?

Keywords

respiratory system, immune system, contamination, aluminum, chemical risk factors, children

Abstract

The study involved 55 children with respiratory disorders aged 6 to 11 years living in the area of influence of exogenous chemical factors. The identification of the marker of cell differentiation CD127-, the level of expression of the Bcl-2 protein, the TNFR receptor was carried out by flow cytometry. Phagocytic activity of cells was studied using formalinized sheep erythrocytes. The IgG content was determined by the method of radial immunodiffusion. The level of beta2-microglobulin was determined by enzyme-linked immunosorbent assay. The functional state of the respiratory system was assessed by spirometry and rhinomanometry methods. Functional reserves were determined by calculating the Skibinskaya index. The prevalence of allergic diseases in the examined children was higher. The allergic rhinitis was diagnosed more often rather than in the comparison group. The prevalence of bronchial asthma, clinical signs of chronic lympho-proliferative diseases significantly exceeded the level of children in the comparison group. Changes in immune reactivity were established relative to the comparison group manifested in an increase in the percentage of phagocytic cells, beta2-microglobulin protein, IgG, CD127-, TNFR, and specific IgG to aluminum. Inhibition of Bcl-2 protein expression was recorded (p <0.05). In children living in the area of influence of exogenous chemical factors, more often than in children of the comparison group, respiratory diseases with an allergic component were diagnosed, reliably associated with the contamination of biological media with aluminum compounds. Immunological examination revealed an imbalance between the humoral and cellular links of immunity: overproduction of specific IgG to aluminum, overexpression of proteins and receptors – beta2-microglobulin, IgG, CD127-, TNFR and Bcl-2 deficiency, which reflects the state of cellular immunodeficiency and the likelihood of allergic manifestations.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - I.N. Alikina
AU  - O.V. Dolgikh
PY  - 2020
DA  - 2020/10/03
TI  - Immune System of Primary School-Age Children With Functional Respiratory Disorders in the Conditions of Anthropogenic Influence
BT  - Proceedings of the International Conference “Health and wellbeing in modern society” (ICHW 2020)
PB  - Atlantis Press
SP  - 68
EP  - 71
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.201001.014
DO  - 10.2991/ahsr.k.201001.014
ID  - Alikina2020
ER  -