Evaluation of the Effectiveness of Bound Forms of Iodine and Zinc in Experimental Models of Iodine Deficiency and Immunodeficiency
- DOI
- 10.2991/ahsr.k.201001.007How to use a DOI?
- Keywords
- iodine deficiency, zinc deficiency, immunodeficiency
- Abstract
The most common micro-elementoses are diseases that occur with iodine and zinc deficiency. The purpose of this work was to evaluate the biological effectiveness of a developed additive containing bound forms of iodine and zinc on experimental models of iodine deficiency and immunodeficiency. The experiments were carried out on white outbred male rats weighing 150–180 grams. The iodine deficiency model was induced by the introduction of the thyrostatic compound tyrosol for 14 days. The immunodeficiency model was induced by the introduction of azathioprine for 7 days. The levels of thyroid hormones and immunoglobulins A, M and G were determined by solid-phase ELISA using standard sets. The intensity of lipid peroxidation and antioxidant status was assessed by conventional methods. A form of iodine and zinc was developed, associated with peptides from soy protein hydrolysate. The existence of an ionic bond with iodine and a covalent bond with zinc was experimentally demonstrated. This additive stimulated the synthesis of thyroid gland hormones and immunoglobulins in the sera of experimental animals, increased the antioxidant status of the organism and reduced the oxidative stress caused by iodine deficiency. The developed additive maybe used for the development of mass-produced foods enriched with iodine and zinc to prevent microelementoses.
- Copyright
- © 2020, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - D.V. Lygdenov AU - A.B. Batorova AU - E.V. Sordonova AU - S.D. Zhamsaranova PY - 2020 DA - 2020/10/03 TI - Evaluation of the Effectiveness of Bound Forms of Iodine and Zinc in Experimental Models of Iodine Deficiency and Immunodeficiency BT - Proceedings of the International Conference “Health and wellbeing in modern society” (ICHW 2020) PB - Atlantis Press SP - 32 EP - 37 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.201001.007 DO - 10.2991/ahsr.k.201001.007 ID - Lygdenov2020 ER -