The Potency of Piperine as Magnesium Bioenhancer in Mice Lung

DOI

10.2991/978-94-6463-112-8_72How to use a DOI?

Keywords

piperine; magnesium; bioenhancer; in vivo; lung

Abstract

Magnesium (Mg) deficiency is found in many disease conditions ranging from infectious diseases to degenerative diseases. In COVID-19, magnesium deficiency is associated with susceptibility to infection and the development of severe infections. In this disease, magnesium has been suggested to play a role in the regulation of the immune system, inflammation, and bronchodilatation. Unfortunately, despite its cheap price and abundant availability in nature, magnesium deficiency is difficult to treat. Deficiency persists even after supplementation. Lack of compliance due to side effects at high doses is also another problem. This study aims to investigate the effect of piperine as a magnesium bioenhancer by measuring the bioavailability of magnesium in the lungs of healthy mice using graphite furnace atomic absorption spectrometry (GF-AAS). In addition, two different administrations were compared, ie. Repeated dose oral administrations (5 times/5 days) and single dose intraperitoneal administrations in which each of them consist of 3 testing substances, ie. Magnesium only (MgSO₄ 100 mg/kg), piperine only (10 mg/kg), and the combination of magnesium and piperine. One group receives no treatment and serves as a control. The results showed that piperine could increase the uptake of magnesium in the lungs. Surprisingly, this effect is independent of magnesium intake because co-administration of magnesium reduced the uptake of magnesium in the lungs. Of note, single intra peritoneal administration shows a much more prominent effect than repeated doses of oral administration. We suggest piperine could be used as a magnesium bioenhancer in the lung. Future studies using different animal models seem warranted.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Tri Yuliani
AU  - Hikmat Hikmat
AU  - Indah D. Dewijanti
AU  - Rizna T. Dewi
AU  - Marissa Angelina
AU  - Sofa Fajriah
AU  - Instiaty Instiaty
PY  - 2023
DA  - 2023/03/01
TI  - The Potency of Piperine as Magnesium Bioenhancer in Mice Lung
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 799
EP  - 806
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_72
DO  - 10.2991/978-94-6463-112-8_72
ID  - Yuliani2023
ER  -