Characterization and Antioxidant Activity of Nanoparticles Loaded Jacfruit Leaf Extract (Artocarpus heterophyllus Lamk.)
- DOI
- 10.2991/ahsr.k.211105.009How to use a DOI?
- Keywords
- antioxidant; chitosan; DPPH; jackfruit leaf extract; nanoparticles
- Abstract
Jackfruit leaves extract (Artocarpus heterophyllus Lamk.) which contained flavonoid as an antioxidant was unstable and sensitive to environmental conditions. Preparation of nanoparticles loaded jackfruit leaf extract aimed to increase the antioxidant activity through optimal delivery system and maintain the stability of flavonoid from jackfruit leaf extract. Nanoparticle preparation used an ionic gelation method with chitosan, sodium alginate, and variation of calcium chloride. Characterization of nanoparticles were particle size, polydispersity index, efficiency of encapsulation, zeta potential, and XRD analysis. Based on the result, the highest percent of encapsulation efficiency in the nanoparticles with the amount of calcium chloride 40 μl was 90,76%. The characterization of nanoparticles, particle size was 244,2 nm, polydispersity index was 0,22, and zeta potential was +26,4 mV. The XRD pattern of nanoparticles loaded jackfruit leaf extract showed jackfruit leaf extract encapsulated into nanoparticles. Antioxidant activity of jackfruit leaf extract increased after encapsulation as indicated by the IC50 for nanoparticles of jackfruit leaf extract was 10,13μg/ml which indicates high antioxidant.
- Copyright
- © 2021 The Authors. Published by Atlantis Press International B.V.
- Open Access
- This is an open access article under the CC BY-NC license.
Cite this article
TY - CONF AU - Dina Permata Wijaya AU - Mardiyanto AU - Herlina AU - Vabiola Besti Delmoda PY - 2021 DA - 2021/11/17 TI - Characterization and Antioxidant Activity of Nanoparticles Loaded Jacfruit Leaf Extract (Artocarpus heterophyllus Lamk.) BT - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021) PB - Atlantis Press SP - 60 EP - 64 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.211105.009 DO - 10.2991/ahsr.k.211105.009 ID - Wijaya2021 ER -