In Vitro Effect of Tetraprenyltoluquinone on Normal Human Leukocyte Cell

DOI

10.2991/ahsr.k.211105.022How to use a DOI?

Keywords

Garcinia cowa; Roxb; leukocyte; MTT assay; tetraprenyltoluquinone

Abstract

Tetraprenyltoluquinone is a compound that was successfully isolated from the hexane fraction of stem bark Garcinia cowa, Roxb. In previous studies, tetraprenyltoluquinone is known to have anticancer and anti-inflammatory activity. The aim of the study is to investigate the impact of tetraprenyltoluquinone on normal human leukocyte cell cultures. Tetraprenyltoluquinone with a concentration between 3.125-1000 μg/mL was tested for cell viability using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and measured at λ 570 nm using a microplate reader. The results showed that tetraprenyltoluquinone was not toxic to human leukocyte cell cultures and had an IC₅₀ of 2588.938 μg/mL.

Copyright

© 2021 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Dira Hefni
AU  - Fatma Sri Wahyuni
AU  - Surya Dharma
AU  - Dachriyanus
AU  - Rielenda Fadhilah
PY  - 2021
DA  - 2021/11/17
TI  - In Vitro Effect of Tetraprenyltoluquinone on Normal Human Leukocyte Cell
BT  - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
PB  - Atlantis Press
SP  - 152
EP  - 154
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211105.022
DO  - 10.2991/ahsr.k.211105.022
ID  - Hefni2021
ER  -