Multicomponent Crystal of Fenofibric Acid- Saccharin: Characterization and Antihyperlipidemic Effectiveness

Salman Umar; Nedita Putri Bandaro; Deni Anggraini; Erizal Zaini

doi:10.2991/ahsr.k.211105.015

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Multicomponent Crystal of Fenofibric Acid- Saccharin: Characterization and Antihyperlipidemic Effectiveness

Authors

Salman Umar¹, Nedita Putri Bandaro¹, Deni Anggraini¹, Erizal Zaini¹^{, *}

¹Department of Pharmaceutics, Faculty of Pharmacy Universitas Andalas, Padang 26163, Indonesia

^*Corresponding author. Email: erizal@phar.unand.ac.id

Corresponding Author

Erizal Zaini

Available Online 17 November 2021.

DOI: 10.2991/ahsr.k.211105.015 How to use a DOI?
Keywords: Fenofibric acid; saccharin; multicomponent crystal; dissolution; antihyperlipidemia
Abstract: Fenofibric acid is an active form of fenofibrate which has an antihyperlipidemic effect. Fenofibric acid belongs to BCS class II, which has low solubility and high permeability. The aim of this study was to form multicomponent crystal of fenofibric acid and saccharin that can increase the solubility and dissolution rate, as well as impact on its effectiveness. The ratio of the mixture of fenofibric acid and saccharin was determined using two phase diagram. Characterizations were carried out by Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), Fourier Transform Infrared (FTIR), and the evaluations carried out are solubility, dissolution rate and antihyperlipidemic effectiveness. Based on the two phase diagram a mixture of fenofibric acid and saccharin produce eutectic point at 1:1 mole ratio. Multicomponent crystal showed a decrease in melting point with DSC analysis, no new crystalline phase was formed in X-ray diffraction analysis and did not show any chemical interactions in FTIR analysis. Multicomponent crystal showed an increase in the solubility and dissolution rate. The results of the effectiveness of antihyperlipidemic showed that multicomponent crystal was more effective than fenofibric acid.
Copyright: © 2021 The Authors. Published by Atlantis Press International B.V.
Open Access: This is an open access article under the CC BY-NC license.

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Volume Title: Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
Series: Advances in Health Sciences Research
Publication Date: 17 November 2021
ISBN: 978-94-6239-450-6
ISSN: 2468-5739
DOI: 10.2991/ahsr.k.211105.015 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC license.

Cite this article

ris enw bib

TY  - CONF
AU  - Salman Umar
AU  - Nedita Putri Bandaro
AU  - Deni Anggraini
AU  - Erizal Zaini
PY  - 2021
DA  - 2021/11/17
TI  - Multicomponent Crystal of Fenofibric Acid- Saccharin: Characterization and Antihyperlipidemic Effectiveness
BT  - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
PB  - Atlantis Press
SP  - 104
EP  - 109
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211105.015
DO  - 10.2991/ahsr.k.211105.015
ID  - Umar2021
ER  -

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