Purified Gambier (Uncaria gambir Roxb.) and Propolis Performance in Male White Mice (Mus musculus L.) Antibody Titer with Measles Vaccine

DOI

10.2991/ahsr.k.211105.035How to use a DOI?

Keywords

antibody titer; purified gambier; propolis; measles vaccine

Abstract

Gambier (Uncaria gambir Roxb.) and propolis showed a beneficial effect on infectious diseases. This study aims to examine the effect of gambier and propolis on the antibodies of white male mice given measles vaccine using the antibody titer method, number, and percentage of different types of leukocytes. Thirty white male mice were used and grouped into six groups (100 mg/kg BW of purified gambier, 200 mg/kg BW of purified gambier, 200 mg/kg BW of purified gambier + 195 mg/kg BW of propolis, 195 mg/kg BW of propolis, 0.5% Na CMC and no treatment). After 14 days of preparation, each group was vaccinated with measles vaccine. On the 28th day, the antibody titer, total leukocyte cells, and the percentage of leukocyte cell types were determined. The results showed that gambier and propolis could increase antibody titer of male white mice. The purified gambier group at a dose of 200 mg/ kg BW + propolis 195 mg/ kg BW was the most optimal compared to the other doses. There was a significant difference (p <0.05) between antibody titer, the total leukocyte cells, and the percentage of lymphocytes of mice that received the combination of purified gambier and propolis. It can be concluded that purified gambier can increase antibody titer, the number of leukocytes, and the percentage of lymphocytes of male mice.

Copyright

© 2021 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Lailaturrahmi
AU  - Rabani Ahmad
AU  - Dwisari Dillasamola
AU  - A. Almahdy
PY  - 2021
DA  - 2021/11/17
TI  - Purified Gambier (Uncaria gambir Roxb.) and Propolis Performance in Male White Mice (Mus musculus L.) Antibody Titer with Measles Vaccine
BT  - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
PB  - Atlantis Press
SP  - 245
EP  - 250
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211105.035
DO  - 10.2991/ahsr.k.211105.035
ID  - 2021
ER  -