Establishing Phylogeny, Functional Profile and Novel Drug for Nipah Virus Encephalitis

DOI

10.2991/978-94-6463-164-7_17How to use a DOI?

Keywords

Nipah virus Encephalitis; Pteropus spp; Microbiome; Functional profile; Phylogeny; Metatranscriptomics sequencing; Gene receptors; Phytocompounds; Docking; Drug designing

Abstract

Background: Nipah virus encephalitis causing microbiome Nipah henipavirus was taken in this work which is the causative factor for encephalitis condition in humans. The fruit bats of Pteropus genus are the natural reservoir and acts as a carrier of this Nipah henipavirus. The phylogeny, functional profile of Nipah virus microbiome was identified by using metatranscriptomic sequencing. The receptor genes involved in the Nipah virus encephalitis mainly L protein and a P gene product – V protein were taken in this work and molecular docking studies were done using the phytocompounds from Centella asiastica with the target protein receptors taken. The computational drug designing was employed to prove the efficiency of the novel drug against the Nipah virus encephalitis disease. From the result of this study, the phytocompound- Arjunolic acid from Centella asiatica plant showed better interactions with the protein receptors with good docking score.

Methodology: Using metatranscriptomic sequencing, the taxonomic phylogeny and functional profile of the microbiome was identified. On using the Krona and GraPhlAn tools, the presence of the microbiome Nipah virus was confirmed. By using Normalised gene families, was able to get the functional profile of the microbiome. The receptor genes involved in the Nipah virus encephalitis mainly L protein and a P gene product – V protein were taken in this work. Using computer- aided drug designing the novel ligands from the medicinal plant – Centella asiatica was further docked with the gene receptors that was taken and the novel drug was designed against nipah virus.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - B. S. Anusha
AU  - Preenon Bagchi
PY  - 2023
DA  - 2023/06/05
TI  - Establishing Phylogeny, Functional Profile and Novel Drug for Nipah Virus Encephalitis
BT  - Proceedings of the Joint 3rd International Conference on Bioinformatics and Data Science (ICBDS 2022)
PB  - Atlantis Press
SP  - 239
EP  - 253
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-164-7_17
DO  - 10.2991/978-94-6463-164-7_17
ID  - Anusha2023
ER  -