Comparison of the Reduction of Uric Acid Level by Administration of Tempuyung (Sonchus arvensis) Leaf Extract and Breadfruit (Artocarpus altilis) Leaf Extract in Hyperuricemic Wistar Rats

DOI

10.2991/assehr.k.200402.046How to use a DOI?

Keywords

tempuyung leaf extract, breadfruit leaf extract, uric acid, hyperuricemia

Abstract

Uric acid is a heterocyclic substance that comes from metabolic breakdown of purine compound in the body. A condition where there is a high uric acid level (>7 mg/dl) in the human body is called hyperuricemia. Some traditional plants that often be used as alternative of hyperuricemia drugs by Indonesian people are tempuyung leaf (Sonchus arvensis) and breadfruit leaf (Artocarpus altilis), both of them contain flavonoid as their active substance which is known to reduce uric acid level in the blood. This research is aimed to compare the influence of administration of tempuyung leaf extract and breadfruit leaf extract as the means of reducing uric acid in male white rats that are made hyperuricemia. This research is an experimental research with Pre and Post Test Control Group Design. The samples of this research were 24 male wistar rats that were divided into four groups randomly, they were positive and negative control groups, treatment group 1 and treatment group 2 which were respectively given dose of tempuyung leaf extract 80 mg/200 gr of BW and 0,75 gr/200 gr of BW of breadfruit leaf extract. The data was analysed by using paired T- test. The result is significant differences (α = 0,05 > p-value = 0,000) of uric acid level before and after treatment were shown in both of treatment groups. Treatment group 2 however showed slightly higher average reduction of uric acid level compared to treatment group 1 (5,8690 vs 5,8600 respectively). In short, administration of breadfruit leaf extract (0,75 gr/200 gr of BW) was slightly more effective compared to tempuyung leaf extract (80 mg/200 gr of BW) in reducing uric acid level of white male Wistar rats.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Tuswandi Ahmad Waly
AU  - Rama Samara Brajawikalpa
AU  - Nurbaiti Nurbaiti
PY  - 2020
DA  - 2020/04/07
TI  - Comparison of the Reduction of Uric Acid Level by Administration of Tempuyung (Sonchus arvensis) Leaf Extract and Breadfruit (Artocarpus altilis) Leaf Extract in Hyperuricemic Wistar Rats
BT  - Proceedings of the International Conference on Agriculture, Social Sciences, Education, Technology and Health (ICASSETH 2019)
PB  - Atlantis Press
SP  - 205
EP  - 207
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.200402.046
DO  - 10.2991/assehr.k.200402.046
ID  - Waly2020
ER  -