In vivo Antiplasmodial Activity of (E) 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one compound in Swiss Mice
- DOI
- 10.2991/hsic-17.2017.66How to use a DOI?
- Keywords
- Anti-plasmodium; ED50; (E) - 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one
- Abstract
Malaria is an infectious disease caused by plasmodium sp. Resistance to antimalarial drug urges the finding of new antimalarial agents. One of the potential agents is a chalcone derivate namely (E) - 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one. Objective : This study aimed to test the effect of (E) - 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one on plasmodium sp infection in vivo by measuring the median effective dose (ED 50). Methods : Swiss mice were divided into 6 groups consisting of control group and treatment groups receiving various doses of tested compound (10 mg, 20 mg, 40 mg, 80 mg and 160 mg /BW/day respectively). Tested compound were given for 7 consecutive days. Malaria model was made by infecting mice with 106 P. Berghei on day 4. Parasitemia were measured on day 5 after infection. ED50 was counted with probit analysis. Result : Probit analysis showed that the ED50 value for (E) - 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one was 17,36 mg / BW. Conclusion : (E) - 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one has a very good anti-plasmodial property
- Copyright
- © 2017, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Lilik Wijayanti AU - Mustofa Mustofa AU - Purwanto Purwanto AU - Muthmainah Muthmainah AU - Suwito Suwito PY - 2017/10 DA - 2017/10 TI - In vivo Antiplasmodial Activity of (E) 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one compound in Swiss Mice BT - Proceedings of the Health Science International Conference (HSIC 2017) PB - Atlantis Press SP - 427 EP - 430 SN - 2468-5739 UR - https://doi.org/10.2991/hsic-17.2017.66 DO - 10.2991/hsic-17.2017.66 ID - Wijayanti2017/10 ER -