Anti Cancer Activity of Active Substances from Mangosteen pericarp (Garcinia mangostana Linn) against T47 D Cell Lines

DOI

10.2991/hsic-17.2017.43How to use a DOI?

Keywords

Garcinia mangostana Linn, bioassay-guided fractionation, active substance against breast cancer

Abstract

Garcinia mangostana Linn (Guttiferae) or commonly know as mangosteen has been reported scientifically as anticancer. In developing a pericarp of G.mangostana as the anticancer phytopharmaceutical product, bioassay-guided fractionation approach was chosen to get active substances to be used as raw material breast-cancer drugs. Objectives:The aim of this study is to get the anticancer substances from the pericarp of G.mangostana that are active against breast cancer cells T47D. Method: Separation of active substances was carried out by column chromatography techniques. Based on the principle of bioassay-guided fractionation, a cytotoxicity assay of ethanolic extract and fractions was performed against T47D human breast cancer cell lines. Results:Cytotoxicity assay of the extract, fraction 2, subfraction 2.2, subfraction 2.2.4, and subfraction 2.2.4.4 provided IC50 values 8.96 ug/mL; 1.80 ug/mL; 1.76 ug/mL; 1.12 ug/mL; and 6.93 ug/mL respectively

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Siti Rofida
AU  - Sukardiman Sukardiman
AU  - Aty Widyawaruyanti
AU  - Lusiana Arifianti
PY  - 2017/10
DA  - 2017/10
TI  - Anti Cancer Activity of Active Substances from Mangosteen pericarp (Garcinia mangostana Linn) against T47 D Cell Lines
BT  - Proceedings of the Health Science International Conference (HSIC 2017)
PB  - Atlantis Press
SP  - 274
EP  - 281
SN  - 2468-5739
UR  - https://doi.org/10.2991/hsic-17.2017.43
DO  - 10.2991/hsic-17.2017.43
ID  - Rofida2017/10
ER  -