Black Cummin Extract (Nigella sativa Linn) on Spatial Memory Performance in Menopausal Model of Rat

DOI

10.2991/hsic-17.2017.40How to use a DOI?

Keywords

Nigella Sativa Extract; Menopausal Model Of Rat; Spatial Memory Performance

Abstract

The loss of the ability for learning and memorizing is a prominent feature of dementia, which affects millions of menopausal women all over the world. Nigella sativa is a herbal medicine known to have estrogenic, antioxidant and neuroprotective effects thought to improve memory function in dementia. Objective : This present study investigated the effect of Nigella sativa extract (NS) administration on the spatial memory performance (SMP) of menopausal model of rat. Methods : Experimental with post test only control group design. Bilateral ovariectomy (OVX) was performed in all rats. Two weeks post OVX, the rat has a hypoestrogen condition. There were 6 experimental groups namely OVX group as control and 5 groups of OVX rats treated with NS (OVX +NS) with each dose of 1,25; 2,5; 5; 10 and 20 mg/kgBB. NS were administered after 2 weeks post OVX by intragastric gavage daily for 4 weeks. After NS administered, SMP was evaluated of each rat for 6 consecutive days using Water Morris Maze (WMZ). The time latency to reach the hidden platform was recorded. Result : On the sixth day of practice, the mean of time latency to reach the hidden platform by OVX+NS group with dose 1,25; 2,5 and 5 mg/kgBB were shorter than control group but not significant (P>0.05), while OVX+NS group in dose 10 and 20mg/kg were longer than control group (P>0.05). Conclusion : NS extract could not increased the SMP of OVX rats. Probably because NS is more effective to use since pre-menopause

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Fathiyah Safithri
AU  - Kusuma Andriani
PY  - 2017/10
DA  - 2017/10
TI  - Black Cummin Extract (Nigella sativa Linn) on Spatial Memory Performance in Menopausal Model of Rat
BT  - Proceedings of the Health Science International Conference (HSIC 2017)
PB  - Atlantis Press
SP  - 254
EP  - 263
SN  - 2468-5739
UR  - https://doi.org/10.2991/hsic-17.2017.40
DO  - 10.2991/hsic-17.2017.40
ID  - Safithri2017/10
ER  -