Proceedings of the Health Science International Conference (HSIC 2017)

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C677T Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism and Treatment Response in Schizophrenia Patients

Authors
Muthmainah Muthmainah, Nova Kurniasari, Mohammad Fanani, Septiawan Debree, Herdaetha Adriestri
Corresponding Author
Muthmainah Muthmainah
Available Online October 2017.
DOI
10.2991/hsic-17.2017.33How to use a DOI?
Keywords
Treatment Response, MTHFR, Polymorphism, Schizophrenia
Abstract

Schizophrenia is one of the most common psychiatric disorders. Antipsychotics are widely used to treat schizophrenia. However, around 20 % of people with schizophrenia fail to respond to antipsychotic treatment. Treatment response is influenced by genetic factor. Polymorphism of APOE, NOTCH4 and COMT gene has been reported to be associated with treatment resistance in schizophrenia. Other gene such as MTHFR gene is considered to be involved in the development and prognosis of schizophrenia. Currently, studies that investigate the association between MTHFR gene polymorphism and treatment response in schizophrenia is very rare, especially in Indonesia. Objective: To examine the association between C677T MTHFR gene polymorphism and therapeutic response in patients with schizophrenia in dr. Zainudin Arif hospital, Surakarta. Method: A total of 60 schizophrenia patients of whom 30 were resistant to treatment and 30 were responsive, took part in the study. Peripheral blood was drawn from the subjects for DNA extraction. MTHFR gene polymorphism was determined with ASO PCR method. Result: There is no significant difference between polymorphism status and treatment response (p = 0.085). Additional analysis revealed that relapse rate significantly influenced treatment response (p = 0.001). Conclusion: C667T MTHFR gene polymorphism is not associated with treatment response in schizophrenia.

Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the Health Science International Conference (HSIC 2017)
Series
Advances in Health Sciences Research
Publication Date
October 2017
ISBN
978-94-6252-413-2
ISSN
2468-5739
DOI
10.2991/hsic-17.2017.33How to use a DOI?
Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Muthmainah Muthmainah
AU  - Nova Kurniasari
AU  - Mohammad Fanani
AU  - Septiawan Debree
AU  - Herdaetha Adriestri
PY  - 2017/10
DA  - 2017/10
TI  - C677T Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism and Treatment Response in Schizophrenia Patients
BT  - Proceedings of the Health Science International Conference (HSIC 2017)
PB  - Atlantis Press
SP  - 207
EP  - 213
SN  - 2468-5739
UR  - https://doi.org/10.2991/hsic-17.2017.33
DO  - 10.2991/hsic-17.2017.33
ID  - Muthmainah2017/10
ER  -