Synthesis of N-methylthieno [2, 3-d] Pyrimidin-4-amine Thienopyrimidine

DOI

10.2991/emcm-16.2017.112How to use a DOI?

Keywords

Thieno [2,3-d] pyrimidine; Phosphoinositide 3-kinase; Synthesis

Abstract

Thieno[2,3-d]pyrimidine is a key intermediate in many biologically active compounds such as GDC-0941 and BKM 120. In this work, a rapid synthetic method for compound (4) was established. The compound (4) was synthesized from the commercially available methyl 2-aminothiophene-3-carboxylate and formimidamide through three steps including condensation reaction, chlorination, and nucleophilic substitution. The structure was confirmed by MS and 1H NMR. Furthermore, the total yield of the three steps was 54%.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Huajun Lei
AU  - Min Wang
AU  - Jiaqian Han
AU  - Zhou Lan
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of N-methylthieno [2, 3-d] Pyrimidin-4-amine Thienopyrimidine
BT  - Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.112
DO  - 10.2991/emcm-16.2017.112
ID  - Lei2017/02
ER  -