Synthesis of 4-Chloro-N, N-Dimethyl Pyridine Car Box Amide

DOI

10.2991/emcm-16.2017.111How to use a DOI?

Keywords

4-chloro-N; N-dimethyl pyridine car box amide; Synthesis; Process optimization

Abstract

Sorafenib (1) in the medical field to show the potential biological activity. Literature on the majority of tumor cells have a high biological activity, such as lymphoma, breast cancer, prostate cancer. However, some synthetic route of Sorafeni has disadvantages, such as low product yield and complicated post-treatment. Therefore, in this paper, the main purpose is to optimize the Sorafeni part of the synthesis route. The effects of reaction reagent, feed and temperature on the yield of the reaction were discussed. The optimized reaction conditions were as follows SOCl2 : POCl3=5:1 and use K2CO3 instead of triethylamine.The structures were confirmed by 1H NMR.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yongli Duan
AU  - Zhimin Li
AU  - Qidong Tang
AU  - Rui Li
AU  - Shan Xu
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of 4-Chloro-N, N-Dimethyl Pyridine Car Box Amide
BT  - Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.111
DO  - 10.2991/emcm-16.2017.111
ID  - Duan2017/02
ER  -