Corticosteroid Derivative Effect to Pregnant Rats on the Brain of Their Offspring

DOI

10.2991/ahsr.k.220103.033How to use a DOI?

Keywords

Corticosteroid derivative effect; Cortineff; rats; brain

Abstract

The work investigated the immediate and distant consequences of the introduction of Cortineff. Cortineff, as a derivative of corticosteroids, has both mineral- and glucocorticoid properties. Moreover, its predominant effects are mineralocorticoid. The injection of Cortineff to pregnant rats caused a number of brain features of their offspring. In one-day rats, they included an increase in the thickness of the cortex and its first layer in the anteroposterior and parietal lobe proper, the density of neurons in the second layer of the anteroposterior lobe, as well as in the II and V layers of the parietal lobe proper, an increase in the size of the nuclei of neurons of the V layer of the anteroposterior lobe and hippocampus. In animals of the experimental group at the age of 40, morphometric differences in the parameters characterizing the neocortex were revealed. They manifested themselves with a larger thickness of the anteroposterior lobe and its first layer. The density of neurons in layer II of the anteroposterior and parietal lobe itself was increased in experimental animals. it is believed that their total number in the cortex was increased compared to the control one. At the same time, the large thickness of the first layer, formed mainly by the processes of deep neurons, can indicate a greater intensity of its development. Reflecting the higher synthetic activity of neocortex neurons, one can consider the reliably large sizes of the nuclei of the neurons of the II layer of the parietal lobe itself and the nuclei of the neurons of the field SA1 hippocampus.

Copyright

© 2022 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

Download article (PDF)

TY  - CONF
AU  - Irina V. Nikolaeva
AU  - Tuyaara P. Sivtseva
AU  - Elena V. Pshennikova
PY  - 2022
DA  - 2022/01/17
TI  - Corticosteroid Derivative Effect to Pregnant Rats on the Brain of Their Offspring
BT  - Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)
PB  - Atlantis Press
SP  - 163
EP  - 166
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220103.033
DO  - 10.2991/ahsr.k.220103.033
ID  - Nikolaeva2022
ER  -