The Use of Green Coffee and Green Tea Extract as Cost-Effective Herbs to Counteract Obesity by Inhibiting PPAR-γ Gene Expression
- DOI
- 10.2991/978-94-6463-140-1_47How to use a DOI?
- Keywords
- Green Coffee; Green Tea; PPAR-γ; Intracellular Lipid Accumulation
- Abstract
The use of cost-effective herbs in the health sector is an exciting challenge in this era. Supported by environmentally friendly manufacturing processes, green tea and coffee can benefit health, one of which is metabolic syndrome (MetS). MetS therapy using green tea and green coffee, besides having health benefits, also has great potential in the economic sector because coffee is one of the largest sources of export commodities in Indonesia. Green tea and green coffee products as functional drinks are expected to be beneficial for health, one of which is obesity as a major risk factor in MetS. The purpose of this research is to determine the therapeutic effect of green tea and green coffee on molecular markers of obesity: gene expression of PPAR-γ and intracellular lipid accumulation from 3T3-L1 pre-adipocytes. Based on the results of this study, it was found that there was a significant difference between PPAR-γ and all groups (p = 0.00), and lipid accumulation between all groups (p = 0.00). There was a positive correlation between PPAR-γ and intracellular lipid accumulation with a p-value = 0.009 and an R = 0.610. Green tea and green coffee prevent obesity through inhibition of PPARγ gene expression which is characterized by decreased intracellular lipid accumulation in differentiated 3T3-L1 adipocytes.
- Copyright
- © 2023 The Author(s)
- Open Access
- Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.
Cite this article
TY - CONF AU - Nur Ida Panca Nugrahini AU - Agustin Krisna Wardani AU - Mohammad Saifur Rohman AU - Erryana Martati AU - Indah Nur Chomsy PY - 2023 DA - 2023/04/30 TI - The Use of Green Coffee and Green Tea Extract as Cost-Effective Herbs to Counteract Obesity by Inhibiting PPAR-γ Gene Expression BT - Proceedings of the 2022 Brawijaya International Conference (BIC 2022) PB - Atlantis Press SP - 466 EP - 476 SN - 2352-5428 UR - https://doi.org/10.2991/978-94-6463-140-1_47 DO - 10.2991/978-94-6463-140-1_47 ID - Nugrahini2023 ER -