Indirect Spectrophotometric Determination of Acetylcysteine in Pharmaceutical Sample using Fe(III)-Sulfosalicylic Acid System

DOI

10.2991/bbe-17.2017.75How to use a DOI?

Keywords

Acetylcysteine, Fe (III), Sulfosalicylic acid, Discoloration spectrophotome-try.

Abstract

In acidic medium, Fe (III) can be reduced to Fe (II) by hydrosulfuryl (-SH) in acetylcysteine molecule, and then using sulfosalicylic acid as chromogenic reagent of Fe (III) to determinate the acetylcysteine indirectly by discoloration spectrophotometry.An accurate fast spectrophotometric method for the determination of acetylcysteine by discoloration spectrophotometry using Fe (III)-sulfosalicylic acid system has been established. This proposed method had been successfully applied to determinate of acetylcysteine in real pharmaceutical, and the results agreed well with pharmacopoeial method.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xin-rong WEN
AU  - Chang-qing TU
PY  - 2017/05
DA  - 2017/05
TI  - Indirect Spectrophotometric Determination of Acetylcysteine in Pharmaceutical Sample using Fe(III)-Sulfosalicylic Acid System
BT  - Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)
PB  - Atlantis Press
SP  - 465
EP  - 470
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-17.2017.75
DO  - 10.2991/bbe-17.2017.75
ID  - WEN2017/05
ER  -