The Role and Mechanism of Exercise for Prevention of Myocardial Fibrosis in Diabetes

DOI

10.2991/bbbs-18.2018.2How to use a DOI?

Keywords

Exercise, Diabetes, myocardial fibrosis, TGF-β1, Smad4.

Abstract

Aims. TGF-β1 plays a role in promoting the transformation of myocardial fibrosis. Smad4 has important functions in maintaining tissue stability and inhibiting cardiac hypertrophy. In this study, we investigated the effect of exercise on TGF-β1/Smad4 and myocardial fibrosis in diabetes. Methods. Male C57BL/6 and db/db mice in exercise group were conducted swimming training for 10 weeks. Mice in control group were sedentary. After exercise intervention, heart weight, body weight and blood glucose were observed. TGF-β1, Smad4 and MMP9 in Cardiac tissues were tested through Western blot. The mRNA lever of TGF-β1 and Smad4 were tested through qRT-PCR. Results. Compared to db/db sedentary group, blood glucose in db/db exercise group reduced significantly (P＜0.05), Heart Index was higher in db/db exercise group than that of db/db sedentary group (P＜0.05). 10 weeks’ swimming training reduced the level of TGF-β1 mRNA, protein and Smad4, MMP9 protein in db/db mice significantly (P＜0.05). Conclusion. Aerobic exercise can improve myocardial fibrosis in diabetes through TGF-β1/Smad4 pathway.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Qi-e Zhu
PY  - 2018/04
DA  - 2018/04
TI  - The Role and Mechanism of Exercise for Prevention of Myocardial Fibrosis in Diabetes
BT  - Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)
PB  - Atlantis Press
SP  - 6
EP  - 11
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbbs-18.2018.2
DO  - 10.2991/bbbs-18.2018.2
ID  - Zhu2018/04
ER  -